Carnitine and acyltransferase in experimental neurogenic atrophies: changes with treatment

Nereo Bresolin, Lorenza Freddo, Vincenzo Tegazzin, Luciano Bet, Mario Armani, Corrado Angelini

Research output: Contribution to journalArticlepeer-review

Abstract

Carnitine level and carnitine palmityl transferase (CPT) activity were investigated in muscles of patients with infantile and juvenile spinal muscular atrophy and polyneuropathies. A significant decrease of both carnitine and CPT was found in the infantile spinal muscular atrophy, but not in the other neurogenic muscle atrophies. These findings were compared with the experimental effect of denervation and reinnervation upon the lipid metabolism in soleus and extensor digitorum longus (EDL) of adult and newborn rats. Twenty-one days after denervation free and total carnitine decreased significantly in both EDL (P

Original languageEnglish
Pages (from-to)170-175
Number of pages6
JournalJournal of Neurology
Volume231
Issue number4
DOIs
Publication statusPublished - Oct 1984

Keywords

  • Carnitine
  • Neurogenic atrophy
  • Oxidative lipid metabolism
  • Treatment

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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