Carotenoid intake and head and neck cancer

Emanuele Leoncini, Valeria Edefonti, Mia Hashibe, Maria Parpinel, Gabriella Cadoni, Monica Ferraroni, Diego Serraino, Keitaro Matsuo, Andrew F. Olshan, Jose P. Zevallos, Deborah M. Winn, Kirsten Moysich, Zuo Feng Zhang, Hal Morgenstern, Fabio Levi, Karl Kelsey, Michael McClean, Cristina Bosetti, Stimson Schantz, Guo Pei YuPaolo Boffetta, Yuan Chin Amy Lee, Shu Chun Chuang, Adriano Decarli, Carlo La Vecchia, Stefania Boccia

Research output: Contribution to journalArticle

Abstract

Food and nutrition play an important role in head and neck cancer (HNC) etiology; however, the role of carotenoids remains largely undefined. We explored the relation of HNC risk with the intake of carotenoids within the International Head and Neck Cancer Epidemiology Consortium. We pooled individual-level data from 10 case–control studies conducted in Europe, North America, and Japan. The analysis included 18,207 subjects (4414 with oral and pharyngeal cancer, 1545 with laryngeal cancer, and 12,248 controls), categorized by quintiles of carotenoid intake from natural sources. Comparing the highest with the lowest quintile, the risk reduction associated with total carotenoid intake was 39 % (95 % CI 29–47 %) for oral/pharyngeal cancer and 39 % (95 % CI 24–50 %) for laryngeal cancer. Intakes of β-carotene equivalents, β-cryptoxanthin, lycopene, and lutein plus zeaxanthin were associated with at least 18 % reduction in the rate of oral and pharyngeal cancer (95 % CI 6–29 %) and 17 % reduction in the rate of laryngeal cancer (95 % CI 0–32 %). The overall protective effect of carotenoids on HNC was stronger for subjects reporting greater alcohol consumption (p
Original languageItalian
Pages (from-to)369-383
JournalEuropean Journal of Epidemiology
Volume31
DOIs
Publication statusPublished - 2016

Cite this

Leoncini, E., Edefonti, V., Hashibe, M., Parpinel, M., Cadoni, G., Ferraroni, M., Serraino, D., Matsuo, K., Olshan, A. F., Zevallos, J. P., Winn, D. M., Moysich, K., Zhang, Z. F., Morgenstern, H., Levi, F., Kelsey, K., McClean, M., Bosetti, C., Schantz, S., ... Boccia, S. (2016). Carotenoid intake and head and neck cancer. European Journal of Epidemiology, 31, 369-383. https://doi.org/10.1007/s10654-015-0036-3