Carotid artery atherosclerosis in hypertensive patients with a functional LDL receptor-related protein 6 gene variant

R. Sarzani, F. Salvi, M. Bordicchia, F. Guerra, I. Battistoni, G. Pagliariccio, L. Carbonari, P. Dessì-Fulgheri, A. Rappelli

Research output: Contribution to journalArticle

Abstract

Background and aims: Rare (611C) and common (1062V) variants of the Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) display reduced activation of Wnt/ß-catenin signaling. The rare gene variant was associated with hypertension, metabolic abnormalities, and early coronary artery disease. We investigated whether the common 1062V LRP6 variant was related to carotid artery atherosclerosis (CAA) in hypertensive patients. Methods and results: Retrospective study of 334 hypertensive patients (

Original languageEnglish
Pages (from-to)150-156
Number of pages7
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume21
Issue number2
DOIs
Publication statusPublished - Feb 2011

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Keywords

  • Carotid atherosclerosis
  • Genetics
  • Hypertension
  • Lipoprotein receptor-related protein 6
  • Wnt/β-catenin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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