Carotid artery intima-media thickness and lacunar versus nonlacunar infarcts

L. M. Cupini, P. Pasqualetti, M. Diomedi, F. Vernieri, M. Silvestrini, B. Rizzato, F. Ferrante, G. Bernardi

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Background and Purpose - Increases in the thickness of the intima and media of the carotid artery have been associated with an increased risk of myocardial infarction and stroke in subjects without a history of cardiovascular disease. Lacunar infarcts, one of the most common subtype of ischemic stroke, show unique pathological and clinicoradiological characteristics. The present study examines the relationship between vascular risk factors, including carotid artery intima-media thickness (IMT), and lacunar versus nonlacunar infarcts. Methods - We collected data from patients with acute ischemic stroke admitted to hospital. Patients and 129 control subjects underwent B-mode ultrasonographic measurements of IMT of the common carotid artery. We examined the association of lacunar and nonlacunar infarcts with age, sex, and potential vascular risk factors. Results - Of 292 adult patients with an acute first-ever ischemic stroke, 96 were considered lacunar and 196 were considered nonlacunar strokes. We did not find a significantly different percentage of diabetes, smoking, hypertension, dyslipidemia, myocardial infarction, and previous transient ischemic attack between the 2 groups of patients. The multinomial logistic regression procedure selected carotid artery IMT and atrial fibrillation as the only independent factors able to discriminate between lacunar and nonlacunar patients. IMT values were significantly higher in patients with nonlacunar stroke versus both those with lacunar stroke and control subjects. Conclusions - The present results indicate the usefulness of noninvasive measurement of IMT with ultrasonic techniques as a diagnostic tool that may help to identify different subtypes of ischemic stroke patients. The noninvasive measurements may have predictive power with respect to lacunar versus nonlacunar infarcts.

Original languageEnglish
Pages (from-to)689-694
Number of pages6
JournalStroke
Volume33
Issue number3
DOIs
Publication statusPublished - 2002

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Carotid Intima-Media Thickness
Carotid Arteries
Stroke
Lacunar Stroke
Myocardial Infarction
Common Carotid Artery
Transient Ischemic Attack
Dyslipidemias
Ultrasonics
Atrial Fibrillation
Cardiovascular Diseases
Logistic Models
Smoking
Hypertension

Keywords

  • Lacunar infarction
  • Risk factors
  • Ultrasonography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Cupini, L. M., Pasqualetti, P., Diomedi, M., Vernieri, F., Silvestrini, M., Rizzato, B., ... Bernardi, G. (2002). Carotid artery intima-media thickness and lacunar versus nonlacunar infarcts. Stroke, 33(3), 689-694. https://doi.org/10.1161/hs0302.103661

Carotid artery intima-media thickness and lacunar versus nonlacunar infarcts. / Cupini, L. M.; Pasqualetti, P.; Diomedi, M.; Vernieri, F.; Silvestrini, M.; Rizzato, B.; Ferrante, F.; Bernardi, G.

In: Stroke, Vol. 33, No. 3, 2002, p. 689-694.

Research output: Contribution to journalArticle

Cupini, LM, Pasqualetti, P, Diomedi, M, Vernieri, F, Silvestrini, M, Rizzato, B, Ferrante, F & Bernardi, G 2002, 'Carotid artery intima-media thickness and lacunar versus nonlacunar infarcts', Stroke, vol. 33, no. 3, pp. 689-694. https://doi.org/10.1161/hs0302.103661
Cupini LM, Pasqualetti P, Diomedi M, Vernieri F, Silvestrini M, Rizzato B et al. Carotid artery intima-media thickness and lacunar versus nonlacunar infarcts. Stroke. 2002;33(3):689-694. https://doi.org/10.1161/hs0302.103661
Cupini, L. M. ; Pasqualetti, P. ; Diomedi, M. ; Vernieri, F. ; Silvestrini, M. ; Rizzato, B. ; Ferrante, F. ; Bernardi, G. / Carotid artery intima-media thickness and lacunar versus nonlacunar infarcts. In: Stroke. 2002 ; Vol. 33, No. 3. pp. 689-694.
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AU - Silvestrini, M.

AU - Rizzato, B.

AU - Ferrante, F.

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