Carotid intima media thickness and coronary atherosclerosis linkage in symptomatic intermediate risk patients evaluated by coronary computed tomography angiography

Andrea Igoren Guaricci, Teresa Arcadi, Natale Daniele Brunetti, Erica Maffei, Deodata Montrone, Chiara Martini, Maria De Luca, Fiorella De Rosa, Domenico Cocco, Massimo Midiri, Filippo Cademartiri, Luca Macarini, Matteo Di Biase, Gianluca Pontone

Research output: Contribution to journalArticlepeer-review

Abstract

Background There is a growing evidence that carotid intima media thickness (CIMT) is associated with coronary artery disease (CAD) and it should be used as a predictor of atherosclerotic burden of coronary arteries. However, these studies have been performed by using invasive coronary angiography (ICA) and in high-risk patients for CAD. The purpose of this study was to evaluate the correlation between CIMT by ultrasound and coronary atherosclerosis in symptomatic intermediate risk patients by coronary computed tomography angiography (CCTA).

Methods We enrolled 204 consecutive symptomatic patients (mean age: 61 ± 10; men: 118) and intermediate risk for CAD. All patients underwent CIMT ultrasound evaluation and CCTA. Coronary artery calcium score (CACS), characteristics of plaques, severity of CAD, segment involvement score (SIS) and Gensini's score were assessed and compared with CIMT values.

Results CIMT has been proved as an independent predictor of a number of coronary artery plaques, overall number of mixed and remodeled plaques, presence of obstructive CAD, high SIS and Gensini's score (HR 1.2, CI 1.05-1.42, p 0.01; HR 1.2, CI 1.01-1.41, p 0.03; HR 9.0, CI 1.37-59.7, p 0.02; HR 21.0, CI 2.40-184, p <0.01; HR 1.2, CI 1.08-1.42, p <0.01; HR 1.2, CI 1.08-1.42, p <0.01, respectively). A cut-off value > 1.3 was associated with a better positive and negative predictive value (100% and 69%) to predict the combined endpoint of presence and mixed and/or remodeled coronary artery plaques.

Conclusions CIMT is an independent predictor of coronary atherosclerotic burden as detected by CCTA in symptomatic intermediate risk patients.

Original languageEnglish
Pages (from-to)988-993
Number of pages6
JournalInternational Journal of Cardiology
Volume176
Issue number3
DOIs
Publication statusPublished - Oct 20 2014

Keywords

  • Carotid intima media thickness
  • Coronary artery disease
  • Coronary atherosclerosis
  • Coronary computed tomography angiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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