Carotid intima-media thickness in psoriatic arthritis: Differences between tumor necrosis factor-α blockers and traditional disease-modifying antirheumatic drugs

Matteo Nicola Dario Di Minno, Salvatore Iervolino, Rosario Peluso, Raffaele Scarpa, Giovanni Di Minno

Research output: Contribution to journalArticlepeer-review

Abstract

Objective-: Subjects with psoriatic arthritis (PsA) have an abnormally high prevalence of vascular risk factors (VRFs) and are predisposed to vascular mortality. Tumor necrosis factor (TNF)-α, a major determinant of inflammation, is involved in atherosclerosis. Ultrasonographic carotid intima-media thickness (C-IMT) evaluation allows for subclinical atherosclerosis detection. Methods and Results-: Two hundred twenty-four PsA patients (120 on TNF-α blockers and 104 on traditional disease-modifying antirheumatic drugs [DMARDs]) underwent a C-IMT ultrasound assessment. As many as 305 matched subjects without any inflammatory/rheumatologic disease served as controls. The C-IMT of PsA subjects without VRFs was higher (P

Original languageEnglish
Pages (from-to)705-712
Number of pages8
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume31
Issue number3
DOIs
Publication statusPublished - Mar 2011

Keywords

  • atherosclerosis
  • inflammation
  • intima-media thickness
  • psoriatic arthritis
  • tumor necrosis factor-α

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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