Carriage of Streptoccoccus pneumoniae in healthy adults aged 60 y or over in a population with very high and long-lasting pneumococcal conjugate vaccine coverage in children: Rationale and perspectives for PCV13 implementation

Filippo Ansaldi, Daniela De Florentiis, Paola Canepa, Antonella Ceravolo, Emanuela Rappazzo, Rocco Iudici, Mariano Martini, Gerardo Botti, Andrea Orsi, Giancarlo Icardi, Paolo Durando

Research output: Contribution to journalArticle

Abstract

A serial cross-sectional study of nasopharyngeal carriage among adults aged 60 y or over was conducted in winter-spring 2012 with the aim to describe circulating Streptococcus pneumoniae in an area, Liguria Administrative Region, where the vaccine was implemented for a decade and coverage in pediatric age group reached a value close to 100% for more than 5 y, determining a picture of very high vaccine immunological pressure. The serotype-specific carriage picture in adults was compared with that observed in children by means of a cross-sectional study performed one year before using the same sampling and laboratory methods. Cluster sampling enrolled 283 adults, representative of the open population. Detection of multi-serotype carriage was performed using, real-time PC R and primer specific PC Rs. Carriage prevalence of participants with at least one positive sample adjusted for age, i.e., period prevalence, was 18.7%, considering the Ligurian population as standard population, showing that the pneumococcal carriage in the elderly is not a rare event as emerged in other surveys. The long-term use of PC V7 has resulted in strong decrease of vaccine types carriage among adults and children. A multivariate analysis showed that age class and contact with children attending day care covariates were strongly associated with Streptococcus pneumoniae carriage. A strong link between the picture observed in <5-y-old children and ≥ 60-y-old adults emerged: a strong correlation of specific-serotype prevalence between adults and children and risk factor analysis supported the role played by interage-group transmission.

Original languageEnglish
Pages (from-to)614-620
Number of pages7
JournalHuman Vaccines and Immunotherapeutics
Volume9
Issue number3
DOIs
Publication statusPublished - 2013

Keywords

  • Carriage
  • Conjugate vaccine
  • Replacement
  • S. pneumoniae
  • Vaccine prevention

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology
  • Medicine(all)

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