Carrier detection in hemophilia A: A cooperative international study. II. The efficacy of a universal discriminant

P. P. Green, P. M. Mannucci, E. Briet, R. Ljung, C. K. Kasper, E. M. Essien, J. Chediak, C. R. Rizza, J. B. Graham

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Abstract

Factor VIII (F.VIII) and von Willebrand factor (VWF):Ag data collected by eight laboratories on a total of 336 obligatory carriers of hemophilia A and 137 normal women were used to answer questions concerning the construction of linear discriminants for carrier detection. It was found: (a) that a 'universal' linear discriminant can be constructed which is suitable for use in all laboratories and is nearly as effective as laboratory-specific discriminants; (b) that inclusion of age and ABO blood type data improved the efficacy of these discriminants; (c) that substitution of alternative assays for F.VIII and VWF:Ag did not generally improve the efficacy of the discriminants over that obtained using the bioassay for F.VIII:C and Laurell's immunoassay for VWF:Ag; (d) that linear discriminants were far more effective than discriminants based on the F.VIII:C/VWF:Ag ratio. A step-wise procedure is given which any laboratory may follow in using the universal discriminant for carrier detection.

Original languageEnglish
Pages (from-to)1560-1567
Number of pages8
JournalBlood
Volume67
Issue number6
Publication statusPublished - 1986

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ASJC Scopus subject areas

  • Hematology

Cite this

Green, P. P., Mannucci, P. M., Briet, E., Ljung, R., Kasper, C. K., Essien, E. M., Chediak, J., Rizza, C. R., & Graham, J. B. (1986). Carrier detection in hemophilia A: A cooperative international study. II. The efficacy of a universal discriminant. Blood, 67(6), 1560-1567.