Carry-over effect on IFN-gamma production induced by allergen-specific immunotherapy

Giorgio Ciprandi, Maria Pia Sormani, Gilberto Filaci, Daniela Fenoglio

Research output: Contribution to journalArticlepeer-review


Background: Allergic rhinitis is characterized by Th2 polarization and defective IFN-γ production. Specific immunotherapy determines an allergen-specific clinical improvement. Aim of the study: It was to evaluate whether a course of pre-seasonal SLIT with pollen allergen extract might affect the in vitro IFN-γ production using Dermatophagoides farinae (Df) allergen as stimulus, in patients presenting with rhinitis due to pollen allergy. Methods: Thirty-nine AR patients with pollen allergy were included in the study. They assumed pre-seasonal SLIT for 3 months. IFN-γ-specific producing cells were assessed by cytokine ELISPOT before and 3 months after the SLIT course end. Results: SLIT provided a significant increase of both pollen-induced and Df-induced IFN-gamma production (p <0.001). Conclusions: The present study provides evidence that though the defective IFN-γ production is allergen-specific in allergic subjects, the SLIT increasing effects on IFN-γ may be non-specific.

Original languageEnglish
Pages (from-to)1622-1625
Number of pages4
JournalInternational Immunopharmacology
Issue number12
Publication statusPublished - Dec 10 2008


  • Allergic rhinitis
  • IFN-γ production
  • Mites
  • Pollens
  • Th1 cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology


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