Cartilage repair procedures associated with high tibial osteotomy in varus knees: Clinical results at 11years' follow-up

A. Ferruzzi, R. Buda, M. Cavallo, A. Timoncini, S. Natali, S. Giannini

Research output: Contribution to journalArticlepeer-review


Background and aim: In this study, the authors retrospectively compared the clinical outcome of middle-aged active patients affected by a varus knee with medial unicompartmental osteoarthritis: the treatment was isolated high tibial osteotomy (HTO) for one group or HTO associated with a cartilage repair procedure, that was autologous chondrocyte implantation (ACI) for one group (HTO. +. ACI) and microfracture (MFX) for the other group (HTO. +. MFX). The purpose of this study was to analyse the clinical outcomes at long-term follow-up. The hypothesis was that a cartilage repair procedure may add some benefit to isolated axial correction. Methods: 56 patients affected by medial osteoarthcritis in a varus knee were retrospectively investigated: 20 patients were treated by HTO, 18 by HTO. +. ACI and 18 by HTO. +. MFX. All patients underwent clinical assessment following HSS and WOMAC rating scores and a radiographic study was performed preoperatively and at follow-up. The statistical analysis confirmed that the three groups of patients were homogeneous regarding clinical, radiographical and anatomopathological patterns; differences have been reported in body mass index (BMI). Results: At final follow-up, improvements in clinical and radiographical results were obtained in all patients. HTO and HTO. +. ACI series showed significantly higher scores compared to the HTO. +. MFX series. Conclusions: At more than 11. years of follow-up, isolated HTO and HTO. +. ACI treatments showed satisfactory results similar to those reported in the literature with no evidence of superiority of the addition of ACI to isolated HTO. MFX associated with HTO provided the worst results in the series.

Original languageEnglish
Pages (from-to)445-450
Number of pages6
Issue number2
Publication statusPublished - 2014


  • Arthritis
  • Cartilage
  • Knee
  • Osteotomy
  • Surgery
  • Varus

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Medicine(all)


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