Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in Northern Italy

Carlo La Vecchia, Eva Negri, Silvia Franceschi, Adriano Decarli

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

A new mutagen, 2-chloro-4-methylthiobutanoic acid, has recently been identified from a nitrite-treated Japanese salted fish. Its structure suggests that it derives from methionine in the presence of salt and nitrite. We thus considered the interaction between intake of methionine, salt, and nitrites on gastric cancer risk using data from a case-control study conducted in Northern Italy on 746 cases of incident histologically confirmed gastric cancer and 2,053 controls in hospital for acute nonneoplastic nondigestive tract disorders. Compared with subjects reporting low methionine and low-salt intake, the odds ratios (ORs) were 2.4 [95% confidence interval (CI) = 1.5-4.0] for those reporting low-salt and high-methionine, 1.5 (95% CI = 1.02.2) for those with high-salt and low-methionine, and 2.8 (95% CI = 1.9- 4.2) for those with high-salt and high methionine intake. Likewise, with reference to nitrites, compared with subjects with low-methionine and low- nitrite intake, the ORs were 1.9 (95% CI = 1.3-2.6) in the high-methionine and low-nitrite stratum, 1.5 (95% CI = 1.0-2.1) in the low-methionine and high-nitrite stratum, and 2.5 (95% CI = 1.9-3.2) in the high-methionine and high-nitrite stratum. All these estimates were statistically significant. Thus the present findings from a large case-control study conducted in a relatively high-incidence area for gastric cancer suggest that a diet rich in methionine, salt, and nitrite is associated with increased gastric cancer risk.

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalNutrition and Cancer
Volume27
Issue number1
Publication statusPublished - 1997

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Nitrites
case-control studies
Methionine
carcinogenesis
nitrites
Italy
Case-Control Studies
methionine
Stomach
Carcinogenesis
stomach
Salts
salts
confidence interval
stomach neoplasms
Confidence Intervals
Stomach Neoplasms
odds ratio
Odds Ratio
salted fish

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Oncology
  • Food Science

Cite this

Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in Northern Italy. / La Vecchia, Carlo; Negri, Eva; Franceschi, Silvia; Decarli, Adriano.

In: Nutrition and Cancer, Vol. 27, No. 1, 1997, p. 65-68.

Research output: Contribution to journalArticle

La Vecchia, C, Negri, E, Franceschi, S & Decarli, A 1997, 'Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in Northern Italy', Nutrition and Cancer, vol. 27, no. 1, pp. 65-68.
La Vecchia, Carlo ; Negri, Eva ; Franceschi, Silvia ; Decarli, Adriano. / Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in Northern Italy. In: Nutrition and Cancer. 1997 ; Vol. 27, No. 1. pp. 65-68.
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