Case-control study on risk factors for premature ovarian failure

Giovanna Testa, Francesca Chiaffarino, Walter Vegetti, Annaelisa Nicolosi, Ilaria Caliari, Federica Alagna, Pier Francesco Bolis, Fabio Parazzini, Pier Giorgio Crosignani

Research output: Contribution to journalArticlepeer-review


Objective of this case-control study was to investigate the potential risk factors for premature ovarian failure (POF). Seventy-three patients with secondary hypergonadotropic amenorrhea and, as control group, 144 women with acute, non-gynecological, non-neoplastic, non-hormone-related diseases were included in the study. Information was obtained on sociodemographic characteristics, gynecological and obstetric data, general life-stile habits, smoking habits and history of selected gynecological and other clinical conditions. A statistically significant association between high education level and POF was found (p = 0.03). Parity was related to a reduced risk of POF and this reduction increased with the number of live births (p = 0.02). No association emerged between POF risk and age at menarche, cycle length and oral contraceptive use. Women with POF could not be distinguished from control women by behavioral and reproductive history, except for lower fertility. The minor influence that reproductive and lifestyle factors have on the occurrence of POF suggests that genetic inheritance plays a more important role.

Original languageEnglish
Pages (from-to)40-43
Number of pages4
JournalGynecologic and Obstetric Investigation
Issue number1
Publication statusPublished - 2001


  • Amenorrhea
  • Epidemiology
  • Premature ovarian failure
  • Risk factors

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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