TY - JOUR
T1 - Case-control study on risk factors for premature ovarian failure
AU - Testa, Giovanna
AU - Chiaffarino, Francesca
AU - Vegetti, Walter
AU - Nicolosi, Annaelisa
AU - Caliari, Ilaria
AU - Alagna, Federica
AU - Bolis, Pier Francesco
AU - Parazzini, Fabio
AU - Crosignani, Pier Giorgio
PY - 2001
Y1 - 2001
N2 - Objective of this case-control study was to investigate the potential risk factors for premature ovarian failure (POF). Seventy-three patients with secondary hypergonadotropic amenorrhea and, as control group, 144 women with acute, non-gynecological, non-neoplastic, non-hormone-related diseases were included in the study. Information was obtained on sociodemographic characteristics, gynecological and obstetric data, general life-stile habits, smoking habits and history of selected gynecological and other clinical conditions. A statistically significant association between high education level and POF was found (p = 0.03). Parity was related to a reduced risk of POF and this reduction increased with the number of live births (p = 0.02). No association emerged between POF risk and age at menarche, cycle length and oral contraceptive use. Women with POF could not be distinguished from control women by behavioral and reproductive history, except for lower fertility. The minor influence that reproductive and lifestyle factors have on the occurrence of POF suggests that genetic inheritance plays a more important role.
AB - Objective of this case-control study was to investigate the potential risk factors for premature ovarian failure (POF). Seventy-three patients with secondary hypergonadotropic amenorrhea and, as control group, 144 women with acute, non-gynecological, non-neoplastic, non-hormone-related diseases were included in the study. Information was obtained on sociodemographic characteristics, gynecological and obstetric data, general life-stile habits, smoking habits and history of selected gynecological and other clinical conditions. A statistically significant association between high education level and POF was found (p = 0.03). Parity was related to a reduced risk of POF and this reduction increased with the number of live births (p = 0.02). No association emerged between POF risk and age at menarche, cycle length and oral contraceptive use. Women with POF could not be distinguished from control women by behavioral and reproductive history, except for lower fertility. The minor influence that reproductive and lifestyle factors have on the occurrence of POF suggests that genetic inheritance plays a more important role.
KW - Amenorrhea
KW - Epidemiology
KW - Premature ovarian failure
KW - Risk factors
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U2 - 10.1159/000052889
DO - 10.1159/000052889
M3 - Article
C2 - 11150874
AN - SCOPUS:0035174611
VL - 51
SP - 40
EP - 43
JO - Gynecologic and Obstetric Investigation
JF - Gynecologic and Obstetric Investigation
SN - 0378-7346
IS - 1
ER -