Case Report: All That Glisters Is Not* Cancer

Claudio Tirelli; Chandra Bortolotto; Patrizia Morbini; Giulia Maria Stella

doi:10.3389/fmed.2020.541629

Case Report: All That Glisters Is Not^* Cancer

Claudio Tirelli, Chandra Bortolotto, Patrizia Morbini, Giulia Maria Stella

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Properly performed staging in non-small-cell lung cancer (NSCLC) is necessary to avoid wrong therapeutic decisions. Here we present a case which manifested as advanced NSCLC but ultimately was composed of two different and rare pathologies. The first is a TTF-1 positive axillary lymph node that could be defined either as an unusual isolated differentiated cancer of unknown primary or as an even rarer case of ectopic lung epithelium which underwent malignant transformation. The second is sarcoidosis, a sarcoid-like alteration, in remission after oral steroids. The main implication of a correct diagnosis regards patient outcome and the avoidance of toxic inappropriate systemic chemotherapy.

Original language	English
Article number	541629
Journal	Frontiers in Medicine
Volume	7
DOIs	https://doi.org/10.3389/fmed.2020.541629
Publication status	Published - Nov 30 2020

Keywords

lung cancer
metastases
origin
sarcoidosis
staging

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.3389/fmed.2020.541629

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title = "Case Report: All That Glisters Is Not* Cancer",

abstract = "Properly performed staging in non-small-cell lung cancer (NSCLC) is necessary to avoid wrong therapeutic decisions. Here we present a case which manifested as advanced NSCLC but ultimately was composed of two different and rare pathologies. The first is a TTF-1 positive axillary lymph node that could be defined either as an unusual isolated differentiated cancer of unknown primary or as an even rarer case of ectopic lung epithelium which underwent malignant transformation. The second is sarcoidosis, a sarcoid-like alteration, in remission after oral steroids. The main implication of a correct diagnosis regards patient outcome and the avoidance of toxic inappropriate systemic chemotherapy.",

keywords = "lung cancer, metastases, origin, sarcoidosis, staging",

author = "Claudio Tirelli and Chandra Bortolotto and Patrizia Morbini and Stella, {Giulia Maria}",

note = "Funding Information: The study was supported by funds Ricerca Corrente from Italian Ministry of Health granted to GS, IRCCS Policlinico San Matteo, Pavia, Italy. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2020 Tirelli, Bortolotto, Morbini and Stella. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

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AU - Stella, Giulia Maria

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N2 - Properly performed staging in non-small-cell lung cancer (NSCLC) is necessary to avoid wrong therapeutic decisions. Here we present a case which manifested as advanced NSCLC but ultimately was composed of two different and rare pathologies. The first is a TTF-1 positive axillary lymph node that could be defined either as an unusual isolated differentiated cancer of unknown primary or as an even rarer case of ectopic lung epithelium which underwent malignant transformation. The second is sarcoidosis, a sarcoid-like alteration, in remission after oral steroids. The main implication of a correct diagnosis regards patient outcome and the avoidance of toxic inappropriate systemic chemotherapy.

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