TY - JOUR
T1 - Case report
T2 - human papilloma virus type 120-related papillomatosis mimicking laryngeal carcinoma
AU - Belvisi, Valeria
AU - Martellucci, Salvatore
AU - Garbuglia, Anna Rosa
AU - Del Borgo, Cosmo
AU - Martellucci, Stanislao
AU - Baiocchini, Andrea
AU - Manicone, Anna Maria
AU - Bagni, Oreste
AU - Mastroianni, Claudio Maria
AU - Gallo, Andrea
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Introduction: The relationship between human papilloma virus (HPV) and upper respiratory tract pathology was better understood in recent years and represents now an issue of particular interest in carcinogenesis and in immunocompromised host. We describe a case in which a rare genotype HPV-related papillomatosis mimics laryngeal carcinoma in an immunocompromised host. Methods: A 54-year-old woman with a history of HIV–HCV coinfection and anal and laryngeal cancer successfully treated some years before was hospitalized for severe dyspnea, cough and dysphagia. Fiberoptic endoscopic evaluation raised the suspicion of tumor relapse showing the presence of a large glottic-supraglottic ulcerated mass. Several laryngeal biopsies demonstrated koilocytosis and p16 expression, according to a possible HPV infection, and focal figures of mild dysplasia of epithelium. 18 F-FDG PET/CT did not show high glycolytic activity at laryngeal level. An invasive upper respiratory tract papillomatosis in an immunocompromised host was suspected because of the patient’s clinical improvement after antiretroviral therapy. Conclusion: Pharyngeal swab and oral rinse harboured the same HPV120 genotype sequence, a betapapillomavirus of recent description and not yet related to any similar clinical presentations.
AB - Introduction: The relationship between human papilloma virus (HPV) and upper respiratory tract pathology was better understood in recent years and represents now an issue of particular interest in carcinogenesis and in immunocompromised host. We describe a case in which a rare genotype HPV-related papillomatosis mimics laryngeal carcinoma in an immunocompromised host. Methods: A 54-year-old woman with a history of HIV–HCV coinfection and anal and laryngeal cancer successfully treated some years before was hospitalized for severe dyspnea, cough and dysphagia. Fiberoptic endoscopic evaluation raised the suspicion of tumor relapse showing the presence of a large glottic-supraglottic ulcerated mass. Several laryngeal biopsies demonstrated koilocytosis and p16 expression, according to a possible HPV infection, and focal figures of mild dysplasia of epithelium. 18 F-FDG PET/CT did not show high glycolytic activity at laryngeal level. An invasive upper respiratory tract papillomatosis in an immunocompromised host was suspected because of the patient’s clinical improvement after antiretroviral therapy. Conclusion: Pharyngeal swab and oral rinse harboured the same HPV120 genotype sequence, a betapapillomavirus of recent description and not yet related to any similar clinical presentations.
KW - HPV 120 genotype
KW - Human immunodeficiency virus (HIV)
KW - Human papilloma virus (HPV)
KW - Laryngeal papillomatosis
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U2 - 10.1007/s15010-017-1028-x
DO - 10.1007/s15010-017-1028-x
M3 - Article
AN - SCOPUS:85019839895
VL - 45
SP - 709
EP - 713
JO - Infection
JF - Infection
SN - 0300-8126
IS - 5
ER -