Case report: Lenvatinib in neoadjuvant setting in a patient affected by invasive poorly differentiated thyroid carcinoma

Stefano Gay, Eleonora Monti, Chiara Trambaiolo Antonelli, Marco Mora, Bruno Spina, Gianluca Ansaldo, Marsida Teliti, Martina Comina, Lucia Conte, Michele Minuto, Elisabetta Varaldo, Simonetta Zupo, Barbara Massa, Silvia Morbelli, Massimo Giusti

Research output: Contribution to journalArticle

Abstract

We report a case of an elderly woman presenting with a huge cervical mass invading the tracheal lumen. Diagnosed as invasive poorly differentiated thyroid cancer, after an endotracheal biopsy, stenting and radiotherapy, it was judged eligible for total thyroidectomy, but surgery was delayed due to pulmonary thromboembolism. The patient was therefore treated with lenvatinib with a neoadjuvant intent until hemodynamic stability was obtained. Thyroidectomy and radioiodine therapy were then performed and the postdose scan revealed an area of modest uptake in the anterior part of the neck. The patient is now in a good clinical status and she continues her follow-up program without any adjuvant therapy.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalFuture Oncology
Volume15
Issue number24s
DOIs
Publication statusPublished - Jan 1 2019

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Thyroidectomy
Thyroid Neoplasms
Pulmonary Embolism
Neck
Radiotherapy
Hemodynamics
Biopsy
Therapeutics
lenvatinib

Keywords

  • case report
  • lenvatinib
  • neoadjuvant
  • thyroid carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Case report : Lenvatinib in neoadjuvant setting in a patient affected by invasive poorly differentiated thyroid carcinoma. / Gay, Stefano; Monti, Eleonora; Trambaiolo Antonelli, Chiara; Mora, Marco; Spina, Bruno; Ansaldo, Gianluca; Teliti, Marsida; Comina, Martina; Conte, Lucia; Minuto, Michele; Varaldo, Elisabetta; Zupo, Simonetta; Massa, Barbara; Morbelli, Silvia; Giusti, Massimo.

In: Future Oncology, Vol. 15, No. 24s, 01.01.2019, p. 13-19.

Research output: Contribution to journalArticle

Gay, S, Monti, E, Trambaiolo Antonelli, C, Mora, M, Spina, B, Ansaldo, G, Teliti, M, Comina, M, Conte, L, Minuto, M, Varaldo, E, Zupo, S, Massa, B, Morbelli, S & Giusti, M 2019, 'Case report: Lenvatinib in neoadjuvant setting in a patient affected by invasive poorly differentiated thyroid carcinoma', Future Oncology, vol. 15, no. 24s, pp. 13-19. https://doi.org/10.2217/fon-2019-0099
Gay, Stefano ; Monti, Eleonora ; Trambaiolo Antonelli, Chiara ; Mora, Marco ; Spina, Bruno ; Ansaldo, Gianluca ; Teliti, Marsida ; Comina, Martina ; Conte, Lucia ; Minuto, Michele ; Varaldo, Elisabetta ; Zupo, Simonetta ; Massa, Barbara ; Morbelli, Silvia ; Giusti, Massimo. / Case report : Lenvatinib in neoadjuvant setting in a patient affected by invasive poorly differentiated thyroid carcinoma. In: Future Oncology. 2019 ; Vol. 15, No. 24s. pp. 13-19.
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