Aims and background. Adoptive immunotherapy can be a therapeutic option to treat cancer patients with advanced-stage disease refractory to conventional therapies. Methods and study design. We used T-cell therapy with autologous antitumor cytotoxic T lymphocytes (CTLs) in a patient with metastatic renal cell carcinoma. Autologous antitumor CTLs obtained by stimulating CD8-enriched cells with dendritic cells pulsed with irradiated apoptotic tumor cells and expanded in vitro were transfused on days +14 and +28 following chemotherapy and every 2 to 4 months thereafter. Results and conclusions. Treatment with high doses of antitumor CTLs proved to be safe and induced immunological responses and long-lasting clinical benefit in our patient. Copyright - Il Pensiero Scientifico Editore.
- Adoptive immunotherapy
- Antitumor cytotoxic T lymphocytes
- Renal cell carcinoma
ASJC Scopus subject areas
- Cancer Research