TY - JOUR
T1 - Case report
T2 - Malignant peritoneal mesothelioma in two siblings
AU - Picklesimer, Amy H.
AU - Zanagnolo, Vanna
AU - Niemann, Theodore H.
AU - Eaton, Lynne A.
AU - Copeland, Larry J.
PY - 2005/11
Y1 - 2005/11
N2 - Background. Mesothelioma is a rare tumor, linked with occupational asbestos exposure. This association has been used to explain clustering of cases within families. Newer evidence, however, supports a possible genetic predisposition for this tumor. Case. Our patient's brother was diagnosed with advanced stage malignant peritoneal mesothelioma in August 1995 at age of 42, he underwent tumor-reductive surgery followed by chemotherapy. He underwent a repeat cytoreductive surgery in September 1996 and further chemotherapy. He died of disease in December 1996. Our patient underwent cytoreductive surgery in May 1999 at age of 49 for advanced stage malignant peritoneal mesothelioma with suboptimal debulking. She received multiple chemotherapy regimens, including most recently experimental targeted agents, for slow progressing disease. She is presently alive with clinical disease 6 years from diagnosis. Conclusion. This is the first report of two siblings of different gender with malignant peritoneal mesothelioma and only average environmental asbestos exposure. It is highly likely that the family described in this case report has some form of inherited susceptibility to malignancy cancer gene, HLA type, or tumor suppressor gene mutation.
AB - Background. Mesothelioma is a rare tumor, linked with occupational asbestos exposure. This association has been used to explain clustering of cases within families. Newer evidence, however, supports a possible genetic predisposition for this tumor. Case. Our patient's brother was diagnosed with advanced stage malignant peritoneal mesothelioma in August 1995 at age of 42, he underwent tumor-reductive surgery followed by chemotherapy. He underwent a repeat cytoreductive surgery in September 1996 and further chemotherapy. He died of disease in December 1996. Our patient underwent cytoreductive surgery in May 1999 at age of 49 for advanced stage malignant peritoneal mesothelioma with suboptimal debulking. She received multiple chemotherapy regimens, including most recently experimental targeted agents, for slow progressing disease. She is presently alive with clinical disease 6 years from diagnosis. Conclusion. This is the first report of two siblings of different gender with malignant peritoneal mesothelioma and only average environmental asbestos exposure. It is highly likely that the family described in this case report has some form of inherited susceptibility to malignancy cancer gene, HLA type, or tumor suppressor gene mutation.
KW - Familial
KW - Mesothelioma
KW - Peritoneum
UR - http://www.scopus.com/inward/record.url?scp=27144543618&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27144543618&partnerID=8YFLogxK
U2 - 10.1016/j.ygyno.2005.06.033
DO - 10.1016/j.ygyno.2005.06.033
M3 - Article
C2 - 16051325
AN - SCOPUS:27144543618
VL - 99
SP - 512
EP - 516
JO - Gynecologic Oncology
JF - Gynecologic Oncology
SN - 0090-8258
IS - 2
ER -