Case report: Reversal of decreased bone mass by antibiotic treatment in a patient with Whipple's disease

Vincenzo Carnevale, Salvatore Minisola, Elisabetta Romagnoli, Rossana Rosso, Adriana Marcheggiano, Carlo Iannoni, Gianfranco Mazzuoli

Research output: Contribution to journalArticle

Abstract

Whipple's disease is a rare systemic illness, with the main clinical feature being severe malabsorption syndrome. Bone involvement in the disease has rarely been described in previous articles. The authors report a case in which an extensive skeletal evaluation was carried out. Even though osteomalacia is generally considered the most typical metabolic bone disease of malabsorption syndromes, bone biopsy demonstrated that osteoporosis was the prominent histologic feature in this patient. On the basis of serial bone mineral density measurements, antibiotic treatment was able to reverse the initial reduced bone mass.

Original languageEnglish
Pages (from-to)145-147
Number of pages3
JournalAmerican Journal of the Medical Sciences
Volume311
Issue number3
DOIs
Publication statusPublished - Mar 1996

Keywords

  • Bone mineral density
  • Malabsorption syndrome
  • Osteomalacia
  • Osteoporosis
  • Whipple's disease

ASJC Scopus subject areas

  • Medicine(all)

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