Case series evidence for improvement of executive functions after late cranioplasty

Nela Jelcic, Alessandro Della Puppa, Ruggero Mottaran, Diego Cecchin, Renzo Manara, Mauro Dam, Annachiara Cagnin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: Craniectomy, used to relieve refractory intracranial pressure in traumatic brain injury (TBI), may cause cognitive deficits which could be improved by skull breach repair. This paper studied whether late cranioplasty improves a specific pattern of cognitive functions. Design: A case series of five TBI patients with craniectomy undergoing late cranioplasty (median interval time: 14 months, range: 12-36). Methods: Longitudinal neuropsychological and brain MRI assessments 1 week before cranioplasty and 3 months later. Results: After cranioplasty, mean score of the verbal fluency test improved compared to pre-cranioplasty (p=0.02). Similarly, significant improvements after cranioplasty were observed in other tests scores exploring executive functions, such as working memory (p=0.03) and speed of attention (p=0.04), independently from the size and site of cranioplasty. Conclusions: The cognitive improvement induced by cranioplasty, even when performed after a long interval from craniectomy, may be due to the restoration of physiological cerebrospinal fluid circulation which, in turn, allows an efficient brain volume transmission signal circulation. The restoration of this essential way of signal communication seems to affect large-scale neuronal networks responsible for the executive functions.

Original languageEnglish
Pages (from-to)1723-1726
Number of pages4
JournalBrain Injury
Volume27
Issue number13-14
DOIs
Publication statusPublished - 2013

Fingerprint

Executive Function
Intracranial Pressure
Brain
Short-Term Memory
Skull
Cognition
Cerebrospinal Fluid
Communication
Traumatic Brain Injury
Case Series
Restoration
Verbal Fluency
Causes
Working Memory
Cognitive Function
Test Scores
Time Interval
Repair

Keywords

  • Craniectomy
  • Cranioplasty
  • Executive functions
  • Volume transmission

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology

Cite this

Jelcic, N., Della Puppa, A., Mottaran, R., Cecchin, D., Manara, R., Dam, M., & Cagnin, A. (2013). Case series evidence for improvement of executive functions after late cranioplasty. Brain Injury, 27(13-14), 1723-1726. https://doi.org/10.3109/02699052.2013.844857

Case series evidence for improvement of executive functions after late cranioplasty. / Jelcic, Nela; Della Puppa, Alessandro; Mottaran, Ruggero; Cecchin, Diego; Manara, Renzo; Dam, Mauro; Cagnin, Annachiara.

In: Brain Injury, Vol. 27, No. 13-14, 2013, p. 1723-1726.

Research output: Contribution to journalArticle

Jelcic, N, Della Puppa, A, Mottaran, R, Cecchin, D, Manara, R, Dam, M & Cagnin, A 2013, 'Case series evidence for improvement of executive functions after late cranioplasty', Brain Injury, vol. 27, no. 13-14, pp. 1723-1726. https://doi.org/10.3109/02699052.2013.844857
Jelcic N, Della Puppa A, Mottaran R, Cecchin D, Manara R, Dam M et al. Case series evidence for improvement of executive functions after late cranioplasty. Brain Injury. 2013;27(13-14):1723-1726. https://doi.org/10.3109/02699052.2013.844857
Jelcic, Nela ; Della Puppa, Alessandro ; Mottaran, Ruggero ; Cecchin, Diego ; Manara, Renzo ; Dam, Mauro ; Cagnin, Annachiara. / Case series evidence for improvement of executive functions after late cranioplasty. In: Brain Injury. 2013 ; Vol. 27, No. 13-14. pp. 1723-1726.
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