Caspase-14 and epidermis maturation

Pierluigi Nicotera, Gerry Melino

Research output: Contribution to journalArticlepeer-review


Caspases are proteases that regulate apoptosis as well as inflammation. Denecker et al. show that caspase-14 controls the maturation of the epidermis by proteolytically processing filaggrin. The ultimate products of this cleavage prevent UVB photodamage and water loss, affecting skin osmolarity and moisture. Although this work sets caspase-14 apart from its family members, it also reinforces their role in host defence responses.

Original languageEnglish
Pages (from-to)621-622
Number of pages2
JournalNature Cell Biology
Issue number6
Publication statusPublished - Jun 2007

ASJC Scopus subject areas

  • Cell Biology

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