Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma

Giulia Fianco, Maria Patrizia Mongiardi, Andrea Levi, Teresa De Luca, Marianna Desideri, Daniela Trisciuoglio, Donatella Del Bufalo, Irene Cinà, Anna Di Benedetto, Marcella Mottolese, Antonietta Gentile, Diego Centonze, Fabrizio Ferrè, Daniela Barilà

Research output: Contribution to journalArticlepeer-review


Caspase-8 is a key player in extrinsic apoptosis and its activity is often downregulated in cancer. However, human Caspase-8 expression is retained in some tumors, including glioblastoma (GBM), suggesting that it may support cancer growth in these contexts. GBM, the most aggressive of the gliomas, is characterized by extensive angiogenesis and by an inflammatory microenvironment that support its development and resistance to therapies. We have recently shown that Caspase-8 sustains neoplastic transformation in vitro in human GBM cell lines. Here, we demonstrate that Caspase-8, through activation of NF-kB, enhances the expression and secretion of VEGF, IL-6, IL-8, IL-1beta and MCP-1, leading to neovascularization and increased resistance to Temozolomide. Importantly, the bioinformatics analysis of microarray gene expression data derived from a set of high-grade human gliomas, shows that high Caspase-8 expression levels correlate with a worse prognosis.

Original languageEnglish
Publication statusPublished - Jun 8 2017


  • Caspase 8
  • Cytokines
  • Drug Resistance, Neoplasm
  • Gene Expression Profiling
  • Glioblastoma
  • Humans
  • Microarray Analysis
  • NF-kappa B
  • Neovascularization, Pathologic
  • Prognosis
  • Vascular Endothelial Growth Factor A
  • Journal Article


Dive into the research topics of 'Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma'. Together they form a unique fingerprint.

Cite this