Malattia da graffio di gatto ieri e oggi

Translated title of the contribution: Cat scratch disease: The past and the present

M. Del Santo, C. Malorgio, T. Not, A. Tommasini, P. Guastalla, F. Zennaro, A. Ventura

Research output: Contribution to journalArticlepeer-review


Background: B. henselae was identified as the etiological agent of cat scratch disease, allowing the setting-up of diagnostic seralogic tests, by IFA or ELISA methods. The traditional clinical findings are represented by a local primary lesion, papular, nodular, or vesicular-pustular, at the site of the scratch, and regional limphadenitis. Moreover, in the last years, several systemic manifestations, more frequent in immunodeficient patients, were attributed to B. henselae. Aim of the study: To report the epidemiology of localized and systemic CSD in our hospital, where, since 1995, an immunoenzymatic assay for anti-B. henselae antibodies (IgM and IgG) detection is available. Materials and methods: A retrospective analysis of clinical diaries of patients with CSD identified from January 1980 to August 1998 was performed. In the typical forms, the diagnosis was assessed by the clinical history of patient's contact with cats, expecially puppies, the onset of lymphadenomegaly and the limphonodal biopsy for B. henselae detection (when performed). In the atypical forms (characterized by fever and/or hepatosplenic abscess, interstitial miliariform pneumonia, spondilytis, encephalitis, chorioretinitis, endocarditis) the diagnosis was performed by an ELISA test. Results: Cat scratch disease was identified in 23 patients (13 males and 10 females, mean-age 8 years): 11 localized and 12 systemic or atypical forms. 16 of the 23 patients and most of the systemic forms (8 of 12) were identifled in the last five years. One of the patients affected by a systemic form was also affected by an immunodeficiency due to a previous bone marrow transplant. Conclusions: Clinical findings in Bartonellosis are heterogeneous. In particular this disease should be suspected in every case of unexplained fever and/or hepatosplenic abscess, interstitial miliariform pneumonia, spondilytis, encephalitis, chorioretinitis, endocarditis even in immunocompetent subjects.

Translated title of the contributionCat scratch disease: The past and the present
Original languageItalian
Pages (from-to)121-128
Number of pages8
JournalRivista Italiana di Pediatria
Issue number1
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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