Neoroectodermal cell lines were assayed for catalase activity after growing for 5 days in the absence or presence of 5 μM all-trans retinoic acid (RA). Only the neuroblastoma and glioblastoma cell lines with higher basal activity showed an enhancement of enzyme activity, ranging from 178% to 519% over untreated cells. Melanoma cell lines, despite showing significant basal catalase activity, failed to produce any change in activity upon RA exposure. Catalase activity was also assayed in fresh brain tissue homogenates, both normal and neoplastic. The results obtained seem to reflect the cell lineage and the degree of differentiation.
|Number of pages||5|
|Journal||Clinical Chemistry and Enzymology Communications|
|Publication status||Published - 1993|
ASJC Scopus subject areas
- Clinical Biochemistry