Catalase activity in neuroectodermal cell lines and tumours

A. M. Cimini, A. Brunori, E. Candi, M. V. Catani, M. P. Ceru

Research output: Contribution to journalArticlepeer-review

Abstract

Neoroectodermal cell lines were assayed for catalase activity after growing for 5 days in the absence or presence of 5 μM all-trans retinoic acid (RA). Only the neuroblastoma and glioblastoma cell lines with higher basal activity showed an enhancement of enzyme activity, ranging from 178% to 519% over untreated cells. Melanoma cell lines, despite showing significant basal catalase activity, failed to produce any change in activity upon RA exposure. Catalase activity was also assayed in fresh brain tissue homogenates, both normal and neoplastic. The results obtained seem to reflect the cell lineage and the degree of differentiation.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalClinical Chemistry and Enzymology Communications
Volume6
Issue number1-2
Publication statusPublished - 1993

Keywords

  • Catalase
  • Glioblastoma
  • Melanoma
  • Neuroblastoma

ASJC Scopus subject areas

  • Clinical Biochemistry

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