Cataplexy: An affair of pleasure or an unpleasant affair?

Valter Tucci, Giuseppe Plazzi

Research output: Contribution to journalArticle


Narcolepsy, cataplexy and emotions form an intriguing triad that fascinates sleep researchers. A novel aspect of narcoleptic patients' behaviours now appears depending on the emotional valence of the context: how can we explain the fact that narcoleptic patients may experience pleasant-triggered (e.g. laughing) cataplexy as well as unpleasant-related drawback performance (Tucci, V., Stegagno, L., Vandi, S., Ferrillo, F., Palomba, D., Vignatelli, L., Ferini-Strambi, L., Montagna, P., Plazzi, G., Emotional information processing in patients with narcolepsy: a psychophysiologic investigation, Sleep 26 (2003) 558-564; Khatami, R., Birkmann, S., Bassetti, C.L., Amygdala dysfunction in narcolepsycataplexy, J. Sleep Res. 16 (2007) 226-229)? With this in mind we postulate that narcolepsy with cataplexy is a complex sleep disorder that, among others, affects the modulation of emotions at different levels: structural, cellular and molecular.

Original languageEnglish
Pages (from-to)90-91
Number of pages2
JournalNeuroscience Letters
Issue number2
Publication statusPublished - Jan 30 2009


  • Cataplexy
  • Emotions
  • Narcolepsy

ASJC Scopus subject areas

  • Neuroscience(all)

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