Catecholamine-induced cardiomyopathy in multiple endocrine neoplasia: A histologic, ultrastructural, and biochemical study

A. Frustaci, F. Loperfido, N. Gentiloni, M. Caldarulo, E. Morgante, M. A. Russo

Research output: Contribution to journalArticle

Abstract

A catecholamine-induced dilated cardiomyopathy is reported in a patient with multiple endocrine neoplasia, type 3. A histologic and ultrastructural study has been undertaken in cardiac biopsy samples, together with determination of myocardial Ca++ and cellular membrane fatty acids. Contraction band necrosis of cardiocytes with supercontraction of sarcomeres progressing to myofibrolysis and increased levels of myocardial Ca++ have been found as morphologic and biochemical abnormalities, respectively. No lipoperoxidation of cellular membranes or an α-adrenergic mediated reduction of coronary supply could be recognized in the study. We indicate a receptor-mediated intracellular Ca++ overload as the main abnormality responsible for myocardial impairment.

Original languageEnglish
Pages (from-to)382-385
Number of pages4
JournalChest
Volume99
Issue number2
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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