Binding to several receptors was compared in kidneys from 3- and 24-month-old rats. In crude membrane preparations of aged kidneys, the number of β2-adrenergic receptors was significantly reduced but the number of total β-adrenoceptors was unchanged. The high-affinity α1-adrenoceptor component was significantly reduced in old rats, whereas the low-affinity component was unchanged. The number of α2-adrenoceptors showed a non-significant decrease. 3H-spiperone binding sites were similar in young and old rats. For each receptor binding the K(D) values were the same in young and old animals. The D1 dopamine receptor was significantly reduced in old rats. In our experiments, age-related changes of specific binding sites in the kidney were selective for some receptors studied and did not seem to be due to general aging-induced membrane modifications. Moreover, the renal and central receptors were sensitive to aging differently in the same animal model.
|Number of pages||5|
|Publication status||Published - 1988|
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