Catecholaminergic Polymorphic Ventricular Tachycardia

Nian Liu, Yanfei Ruan, Silvia G. Priori

Research output: Contribution to journalArticlepeer-review

Abstract

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a highly malignant form of arrhythmogenic disorder characterized by exercise- or emotional-induced polymorphic ventricular tachycardia in the absence of detectable structural heart disease. Because of the typical pattern of arrhythmias (bidirectional ventricular tachycardia and the occurrence and severity of arrhythmia correlated well with exercise workload) during exercise stress test, CPVT can be identified promptly. Molecular genetic screening of the genes encoding the cardiac ryanodine receptor and calsequestrin is critical to confirm uncertain diagnosis of CPVT. With the exception of β-blockers, no pharmacologic therapy of proven effectiveness is available: although β-blockers reduce the occurrence of ventricular tachycardia, 30% of patients treated with β-blockers still experience cardiac arrhythmias and eventually require implantable cardioverter defibrillator implantation to prevent cardiac arrest.

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalProgress in Cardiovascular Diseases
Volume51
Issue number1
DOIs
Publication statusPublished - Jul 2008

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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