Catecolamine e betabloccanti nello scompenso cardiaco: alcune riflessioni fisiopatologiche e farmacologiche.

Translated title of the contribution: Catecholamines and beta-blockers in heart failure: some physiopathological and pharmacological reflections

E. Pasini, C. Opasich, R. Aquilani

Research output: Contribution to journalArticlepeer-review

Abstract

Although in the past the use of beta-blockers was considered inadvisable in patients with chronic heart failure, recent evidence strongly recommends the use of these drugs for chronic heart failure due to their positive effects on mortality and hospitalization. This paper analyzes some of the possible mechanisms responsible for the positive action of beta-blockers in heart failure. In fact, the effects of reducing sympathetic activity by beta-blockers on the myocardium, skeletal muscle, inflammatory system, metabolism of free fatty acids and glucose, insulin resistance, serum electrolytes, renal function and oxygen free radical generation are illustrated and discussed.

Translated title of the contributionCatecholamines and beta-blockers in heart failure: some physiopathological and pharmacological reflections
Original languageItalian
Pages (from-to)171-179
Number of pages9
JournalItalian Heart Journal
Volume1
Issue number2 Suppl
Publication statusPublished - Feb 2000

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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