Catecholamines and vitiligo.

A. Morrone, M. Picardo, C. de Luca, O. Terminali, S. Passi, F. Ippolito

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

The levels of some catecholamine metabolites, namely homovanillic acid (HVA), vanilmandelic acid (VMA), 3-methoxytyramine (MT), normetanephrine (NMN), metanephrine (MN), 3,4-dihydroxy mandelic acid (DOMAC), and 3,4-dihydroxy phenylacetic acid (DOPAC), have been evaluated in the 24 hr urines of 150 patients affected with different types of vitiligo and in 50 healthy age-matched individuals. The patients were divided into three groups according to the different phases of the disease. The first group included subjects affected either with the early active phase or with progressive increase in both number and/or the size of previous lesions. The second group included patients in whom no new lesions had appeared for between 4-8 months. In the third group the white areas had been stable for 1-5 years. The first and second groups showed values of HVA and VMA from 4 to 10 times and from 1/2 to 3 times higher respectively than those of controls, while no significant differences were found between the third group and controls. Our results clearly show that a significant increase of urinary levels of HVA and VMA, deriving respectively from dopamine and from norepinephrine and epinephrine characterizes the onset and the progressive active phases of vitiligo, irrespective of the type of distribution. The increased release of catecholamines from the autonomic nerve endings in the microenvironment of melanocytes in the affected skin areas might be involved in the etiopathogenesis of vitiligo through two main mechanisms: (1) a direct cytotoxic action of catecholamines and/or their o-diphenol catabolites; (2) an indirect action.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalPigment Cell Research
Volume5
Issue number2
Publication statusPublished - Mar 1992

Fingerprint

homovanillic acid
Vanilmandelic Acid
Homovanillic Acid
Vitiligo
catecholamines
Catecholamines
acids
mandelic acid
Normetanephrine
Metanephrine
phenylacetic acid
metabolites
Autonomic Pathways
nerve endings
Nerve Endings
melanocytes
Melanocytes
epinephrine
Metabolites
norepinephrine

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Plant Science
  • Cell Biology
  • Clinical Biochemistry
  • Developmental Biology

Cite this

Morrone, A., Picardo, M., de Luca, C., Terminali, O., Passi, S., & Ippolito, F. (1992). Catecholamines and vitiligo. Pigment Cell Research, 5(2), 65-69.

Catecholamines and vitiligo. / Morrone, A.; Picardo, M.; de Luca, C.; Terminali, O.; Passi, S.; Ippolito, F.

In: Pigment Cell Research, Vol. 5, No. 2, 03.1992, p. 65-69.

Research output: Contribution to journalArticle

Morrone, A, Picardo, M, de Luca, C, Terminali, O, Passi, S & Ippolito, F 1992, 'Catecholamines and vitiligo.', Pigment Cell Research, vol. 5, no. 2, pp. 65-69.
Morrone A, Picardo M, de Luca C, Terminali O, Passi S, Ippolito F. Catecholamines and vitiligo. Pigment Cell Research. 1992 Mar;5(2):65-69.
Morrone, A. ; Picardo, M. ; de Luca, C. ; Terminali, O. ; Passi, S. ; Ippolito, F. / Catecholamines and vitiligo. In: Pigment Cell Research. 1992 ; Vol. 5, No. 2. pp. 65-69.
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