Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer's disease

Tiziana Ingegni, Giuseppe Nocentini, Elena Mariani, Liana Spazzafumo, M. Cristina polidori, Antonio Cherubini, Marco Catani, Donatella Cadini, Umberto Senin, Patrizia Mecocci

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Abstract

Alzheimer's disease (AD) is the most frequent cause of dementia in elderly people. Different pathological pathways have been involved in the development of late-onset AD. Among them, numerous genes have been proposed as pathogenetic factors acting independently or interactively. It has been suggested that the cathepsin D gene (CTSD) is associated with late-onset AD. We analyzed an exonic polymorphism of the CTSD gene [C→T (Ala→Val) transition at position 224] in 142 AD patients and 120 controls. Our data indicate no significant association between this polymorphism and the risk of AD. Likewise there was no association between CTSD polymorphism and the apolipoprotein E genotype in the risk of developing AD.

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalDementia and Geriatric Cognitive Disorders
Volume16
Issue number3
DOIs
Publication statusPublished - 2003

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Cathepsin D
  • Genetics
  • Polymorphism

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

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    Ingegni, T., Nocentini, G., Mariani, E., Spazzafumo, L., polidori, M. C., Cherubini, A., Catani, M., Cadini, D., Senin, U., & Mecocci, P. (2003). Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 16(3), 151-155. https://doi.org/10.1159/000071003