Cathepsin E in antigen-presenting Langerhans and interdigitating reticulum cells. Its possible role in antigen processing.

E. Solcia, M. Paulli, E. Silini, R. Fiocca, G. Finzi, S. Kindl, E. Boveri, F. Bosi, M. Cornaggia, C. Capella

Research output: Contribution to journalArticle

Abstract

A specific rabbit anti-human cathepsin E serum detected this aspartic proteinase in Langerhans cells of the skin, in interdigitating reticulum cells of lymph nodes and spleen and in histiocytosis X cells, but not in macrophages. Immunoblotting of tissue extracts confirmed the presence of cathepsin E in skin and lymph nodes. Electron immunocytochemistry with the protein A gold technique localized cathepsin E in the endoplasmic reticulum and in endosomal vesicles of both interdigitating and Langerhans cells, likely involving Birbeck bodies. A role of endosomal cathepsin E in antigen processing is suggested.

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalEuropean journal of histochemistry : EJH
Volume37
Issue number1
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Cell Biology
  • Developmental Biology
  • Anatomy

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