Catheter ablation and antiarrhythmic drugs for haemodynamically tolerated post-infarction ventricular tachycardia: Long-term outcome in relation to acute electrophysiological findings

P. Della Bella, R. De Ponti, J. A S Uriarte, C. Tondo, C. Klersy, C. Carbucicchio, C. Storti, S. Riva, M. Longobardi

Research output: Contribution to journalArticle

Abstract

Aims: Radiofrequency catheter ablation is effective at terminating ventricular tachycardia, but the overall clinical role of the technique in patients with a prior myocardial infarction is still debated, due to the uncertainties of the long-term reliability of the procedure. The purpose of this study was to prospectively investigate the relationship between acute results obtained by catheter ablation and long-term outcome in a homogeneous population of patients with post-myocardial infarction ventricular tachycardia. Methods and Results: One hundred and twenty-four consecutive patients with recurrent, drug-refractory, haemodynamically tolerated ventricular tachycardia were included in the study. This population accounted for 30% of the patients with post-myocardial infarction ventricular tachycardia admitted between April 1992 and September 1997 to the investigating centres. The ablation was successful in eliminating sustained ventricular tachycardia in 91 of them (73%); a partial result was obtained in 21 (17%) and failure in 12 (10%). Low dose amiodarone and/or beta-blockers were maintained in 86% of the patients. Over a median follow-up of 41·5 months (interquartile range 30·5-59·5 months), there were 15 deaths (12%), three of which were sudden (2·4%); the 12 remaining patients died of heart failure. Event-free survival analysis showed a significally lower ventricular tachycardia recurrence rate in patients with a successful procedure as compared to those with failure or a partial result (19% vs 53% at one year and 27% vs 60% at 3 years, P=0.003). A repeat procedure was performed in 15 patients with early recurrences and was followed in all by long-term success. Of those who submitted to a second procedure, 93/124 patients (75%) are free of ventricular tachycardia recurrences. An implantable cardioverter-defibrillator (ICD), following procedure failure, was implanted in 13 patients (11%) of the study population. Conclusions: Radiofrequency catheter ablation is effective in a wide population of patients with recurrent tolerated ventricular tachycardia, with very low sudden death and cardiac mortality rates over the long-term. Persistent ventricular tachycardia inducibility after catheter ablation requires an ICD implant and/or repeat ablation.

Original languageEnglish
Pages (from-to)414-424
Number of pages11
JournalEuropean Heart Journal
Volume23
Issue number5
DOIs
Publication statusPublished - Mar 2002

Fingerprint

Catheter Ablation
Anti-Arrhythmia Agents
Ventricular Tachycardia
Infarction
Implantable Defibrillators
Myocardial Infarction
Recurrence
Population
Amiodarone
Sudden Cardiac Death
Survival Analysis
Disease-Free Survival
Uncertainty
Heart Failure

Keywords

  • Catheter ablation
  • Myocardial infarction
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{08289aa8db2f405aabc0e9bede650479,
title = "Catheter ablation and antiarrhythmic drugs for haemodynamically tolerated post-infarction ventricular tachycardia: Long-term outcome in relation to acute electrophysiological findings",
abstract = "Aims: Radiofrequency catheter ablation is effective at terminating ventricular tachycardia, but the overall clinical role of the technique in patients with a prior myocardial infarction is still debated, due to the uncertainties of the long-term reliability of the procedure. The purpose of this study was to prospectively investigate the relationship between acute results obtained by catheter ablation and long-term outcome in a homogeneous population of patients with post-myocardial infarction ventricular tachycardia. Methods and Results: One hundred and twenty-four consecutive patients with recurrent, drug-refractory, haemodynamically tolerated ventricular tachycardia were included in the study. This population accounted for 30{\%} of the patients with post-myocardial infarction ventricular tachycardia admitted between April 1992 and September 1997 to the investigating centres. The ablation was successful in eliminating sustained ventricular tachycardia in 91 of them (73{\%}); a partial result was obtained in 21 (17{\%}) and failure in 12 (10{\%}). Low dose amiodarone and/or beta-blockers were maintained in 86{\%} of the patients. Over a median follow-up of 41·5 months (interquartile range 30·5-59·5 months), there were 15 deaths (12{\%}), three of which were sudden (2·4{\%}); the 12 remaining patients died of heart failure. Event-free survival analysis showed a significally lower ventricular tachycardia recurrence rate in patients with a successful procedure as compared to those with failure or a partial result (19{\%} vs 53{\%} at one year and 27{\%} vs 60{\%} at 3 years, P=0.003). A repeat procedure was performed in 15 patients with early recurrences and was followed in all by long-term success. Of those who submitted to a second procedure, 93/124 patients (75{\%}) are free of ventricular tachycardia recurrences. An implantable cardioverter-defibrillator (ICD), following procedure failure, was implanted in 13 patients (11{\%}) of the study population. Conclusions: Radiofrequency catheter ablation is effective in a wide population of patients with recurrent tolerated ventricular tachycardia, with very low sudden death and cardiac mortality rates over the long-term. Persistent ventricular tachycardia inducibility after catheter ablation requires an ICD implant and/or repeat ablation.",
keywords = "Catheter ablation, Myocardial infarction, Ventricular tachycardia",
author = "{Della Bella}, P. and {De Ponti}, R. and Uriarte, {J. A S} and C. Tondo and C. Klersy and C. Carbucicchio and C. Storti and S. Riva and M. Longobardi",
year = "2002",
month = "3",
doi = "10.1053/euhj.2001.2804",
language = "English",
volume = "23",
pages = "414--424",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
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}

TY - JOUR

T1 - Catheter ablation and antiarrhythmic drugs for haemodynamically tolerated post-infarction ventricular tachycardia

T2 - Long-term outcome in relation to acute electrophysiological findings

AU - Della Bella, P.

AU - De Ponti, R.

AU - Uriarte, J. A S

AU - Tondo, C.

AU - Klersy, C.

AU - Carbucicchio, C.

AU - Storti, C.

AU - Riva, S.

AU - Longobardi, M.

PY - 2002/3

Y1 - 2002/3

N2 - Aims: Radiofrequency catheter ablation is effective at terminating ventricular tachycardia, but the overall clinical role of the technique in patients with a prior myocardial infarction is still debated, due to the uncertainties of the long-term reliability of the procedure. The purpose of this study was to prospectively investigate the relationship between acute results obtained by catheter ablation and long-term outcome in a homogeneous population of patients with post-myocardial infarction ventricular tachycardia. Methods and Results: One hundred and twenty-four consecutive patients with recurrent, drug-refractory, haemodynamically tolerated ventricular tachycardia were included in the study. This population accounted for 30% of the patients with post-myocardial infarction ventricular tachycardia admitted between April 1992 and September 1997 to the investigating centres. The ablation was successful in eliminating sustained ventricular tachycardia in 91 of them (73%); a partial result was obtained in 21 (17%) and failure in 12 (10%). Low dose amiodarone and/or beta-blockers were maintained in 86% of the patients. Over a median follow-up of 41·5 months (interquartile range 30·5-59·5 months), there were 15 deaths (12%), three of which were sudden (2·4%); the 12 remaining patients died of heart failure. Event-free survival analysis showed a significally lower ventricular tachycardia recurrence rate in patients with a successful procedure as compared to those with failure or a partial result (19% vs 53% at one year and 27% vs 60% at 3 years, P=0.003). A repeat procedure was performed in 15 patients with early recurrences and was followed in all by long-term success. Of those who submitted to a second procedure, 93/124 patients (75%) are free of ventricular tachycardia recurrences. An implantable cardioverter-defibrillator (ICD), following procedure failure, was implanted in 13 patients (11%) of the study population. Conclusions: Radiofrequency catheter ablation is effective in a wide population of patients with recurrent tolerated ventricular tachycardia, with very low sudden death and cardiac mortality rates over the long-term. Persistent ventricular tachycardia inducibility after catheter ablation requires an ICD implant and/or repeat ablation.

AB - Aims: Radiofrequency catheter ablation is effective at terminating ventricular tachycardia, but the overall clinical role of the technique in patients with a prior myocardial infarction is still debated, due to the uncertainties of the long-term reliability of the procedure. The purpose of this study was to prospectively investigate the relationship between acute results obtained by catheter ablation and long-term outcome in a homogeneous population of patients with post-myocardial infarction ventricular tachycardia. Methods and Results: One hundred and twenty-four consecutive patients with recurrent, drug-refractory, haemodynamically tolerated ventricular tachycardia were included in the study. This population accounted for 30% of the patients with post-myocardial infarction ventricular tachycardia admitted between April 1992 and September 1997 to the investigating centres. The ablation was successful in eliminating sustained ventricular tachycardia in 91 of them (73%); a partial result was obtained in 21 (17%) and failure in 12 (10%). Low dose amiodarone and/or beta-blockers were maintained in 86% of the patients. Over a median follow-up of 41·5 months (interquartile range 30·5-59·5 months), there were 15 deaths (12%), three of which were sudden (2·4%); the 12 remaining patients died of heart failure. Event-free survival analysis showed a significally lower ventricular tachycardia recurrence rate in patients with a successful procedure as compared to those with failure or a partial result (19% vs 53% at one year and 27% vs 60% at 3 years, P=0.003). A repeat procedure was performed in 15 patients with early recurrences and was followed in all by long-term success. Of those who submitted to a second procedure, 93/124 patients (75%) are free of ventricular tachycardia recurrences. An implantable cardioverter-defibrillator (ICD), following procedure failure, was implanted in 13 patients (11%) of the study population. Conclusions: Radiofrequency catheter ablation is effective in a wide population of patients with recurrent tolerated ventricular tachycardia, with very low sudden death and cardiac mortality rates over the long-term. Persistent ventricular tachycardia inducibility after catheter ablation requires an ICD implant and/or repeat ablation.

KW - Catheter ablation

KW - Myocardial infarction

KW - Ventricular tachycardia

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