Cause and effect of microenvironmental acidosis on bone metastases

Research output: Contribution to journalReview article

Abstract

Skeletal involvement is a frequent and troublesome complication in advanced cancers. In the process of tumor cells homing to the skeleton to form bone metastases (BM), different mechanisms allow tumor cells to interact with cells of the bone microenvironment and seed in the bone tissue. Among these, tumor acidosis has been directly associated with tumor invasion and aggressiveness in several types of cancer although it has been less explored in the context of BM. In bone, the association of local acidosis and cancer invasiveness is even more important for tumor expansion since the extracellular matrix is formed by both organic and hard inorganic matrices and bone cells are used to sense protons and adapt or react to a low pH to maintain tissue homeostasis. In the BM microenvironment, increased concentration of protons may derive not only from glycolytic tumor cells but also from tumor-induced osteoclasts, the bone-resorbing cells, and may influence the progression or symptoms of BM in many different ways, by directly enhancing cancer cell motility and aggressiveness, or by modulating the functions of bone cells versus a pro-tumorigenic phenotype, or by inducing bone pain. In this review, we will describe and discuss the cause of acidosis in BM, its role in BM microenvironment, and which are the final effectors that may be targeted to treat metastatic patients.

Original languageEnglish
Pages (from-to)133-147
Number of pages15
JournalCancer and Metastasis Reviews
Volume38
Issue number1-2
Early online dateMar 2 2019
DOIs
Publication statusPublished - Jun 2019

Fingerprint

Acidosis
Neoplasm Metastasis
Bone and Bones
Neoplasms
Protons
Cellular Microenvironment
Bone Matrix
Osteoclasts
Skeleton
Cell Movement
Extracellular Matrix
Seeds
Homeostasis
Phenotype
Pain

Keywords

  • Bone metastases
  • Acidosis
  • Osteoclast
  • Tumor microenvironment
  • Bone resorption
  • Pain

Cite this

Cause and effect of microenvironmental acidosis on bone metastases. / Avnet, Sofia; Di Pompo, Gemma; Lemma, Silvia; Baldini, Nicola.

In: Cancer and Metastasis Reviews, Vol. 38, No. 1-2, 06.2019, p. 133-147.

Research output: Contribution to journalReview article

@article{7e4e5ea6c5d946d0b0a308d8f4cf8640,
title = "Cause and effect of microenvironmental acidosis on bone metastases",
abstract = "Skeletal involvement is a frequent and troublesome complication in advanced cancers. In the process of tumor cells homing to the skeleton to form bone metastases (BM), different mechanisms allow tumor cells to interact with cells of the bone microenvironment and seed in the bone tissue. Among these, tumor acidosis has been directly associated with tumor invasion and aggressiveness in several types of cancer although it has been less explored in the context of BM. In bone, the association of local acidosis and cancer invasiveness is even more important for tumor expansion since the extracellular matrix is formed by both organic and hard inorganic matrices and bone cells are used to sense protons and adapt or react to a low pH to maintain tissue homeostasis. In the BM microenvironment, increased concentration of protons may derive not only from glycolytic tumor cells but also from tumor-induced osteoclasts, the bone-resorbing cells, and may influence the progression or symptoms of BM in many different ways, by directly enhancing cancer cell motility and aggressiveness, or by modulating the functions of bone cells versus a pro-tumorigenic phenotype, or by inducing bone pain. In this review, we will describe and discuss the cause of acidosis in BM, its role in BM microenvironment, and which are the final effectors that may be targeted to treat metastatic patients.",
keywords = "Bone metastases, Acidosis, Osteoclast, Tumor microenvironment, Bone resorption, Pain",
author = "Sofia Avnet and {Di Pompo}, Gemma and Silvia Lemma and Nicola Baldini",
year = "2019",
month = "6",
doi = "10.1007/s10555-019-09790-9",
language = "English",
volume = "38",
pages = "133--147",
journal = "Cancer and Metastasis Reviews",
issn = "0167-7659",
publisher = "Springer Netherlands",
number = "1-2",

}

TY - JOUR

T1 - Cause and effect of microenvironmental acidosis on bone metastases

AU - Avnet, Sofia

AU - Di Pompo, Gemma

AU - Lemma, Silvia

AU - Baldini, Nicola

PY - 2019/6

Y1 - 2019/6

N2 - Skeletal involvement is a frequent and troublesome complication in advanced cancers. In the process of tumor cells homing to the skeleton to form bone metastases (BM), different mechanisms allow tumor cells to interact with cells of the bone microenvironment and seed in the bone tissue. Among these, tumor acidosis has been directly associated with tumor invasion and aggressiveness in several types of cancer although it has been less explored in the context of BM. In bone, the association of local acidosis and cancer invasiveness is even more important for tumor expansion since the extracellular matrix is formed by both organic and hard inorganic matrices and bone cells are used to sense protons and adapt or react to a low pH to maintain tissue homeostasis. In the BM microenvironment, increased concentration of protons may derive not only from glycolytic tumor cells but also from tumor-induced osteoclasts, the bone-resorbing cells, and may influence the progression or symptoms of BM in many different ways, by directly enhancing cancer cell motility and aggressiveness, or by modulating the functions of bone cells versus a pro-tumorigenic phenotype, or by inducing bone pain. In this review, we will describe and discuss the cause of acidosis in BM, its role in BM microenvironment, and which are the final effectors that may be targeted to treat metastatic patients.

AB - Skeletal involvement is a frequent and troublesome complication in advanced cancers. In the process of tumor cells homing to the skeleton to form bone metastases (BM), different mechanisms allow tumor cells to interact with cells of the bone microenvironment and seed in the bone tissue. Among these, tumor acidosis has been directly associated with tumor invasion and aggressiveness in several types of cancer although it has been less explored in the context of BM. In bone, the association of local acidosis and cancer invasiveness is even more important for tumor expansion since the extracellular matrix is formed by both organic and hard inorganic matrices and bone cells are used to sense protons and adapt or react to a low pH to maintain tissue homeostasis. In the BM microenvironment, increased concentration of protons may derive not only from glycolytic tumor cells but also from tumor-induced osteoclasts, the bone-resorbing cells, and may influence the progression or symptoms of BM in many different ways, by directly enhancing cancer cell motility and aggressiveness, or by modulating the functions of bone cells versus a pro-tumorigenic phenotype, or by inducing bone pain. In this review, we will describe and discuss the cause of acidosis in BM, its role in BM microenvironment, and which are the final effectors that may be targeted to treat metastatic patients.

KW - Bone metastases

KW - Acidosis

KW - Osteoclast

KW - Tumor microenvironment

KW - Bone resorption

KW - Pain

U2 - 10.1007/s10555-019-09790-9

DO - 10.1007/s10555-019-09790-9

M3 - Review article

C2 - 30825056

VL - 38

SP - 133

EP - 147

JO - Cancer and Metastasis Reviews

JF - Cancer and Metastasis Reviews

SN - 0167-7659

IS - 1-2

ER -