Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias: An EBMT analysis of lethal infectious complications and changes over calendar time

A. Gratwohl; R. Brand; F. Frassoni; V. Rocha; D. Niederwieser; P. Reusser; H. Einsele; C. Cordonnier; A. Urbano-Ispizua; A. Baur; P. Elvy; V. Chesnels; N. C. Gorin; P. Ljungman; C. Ruiz de Elvira; J. P. Jouet; A. Hagenbeek; Av Biezen; N. Tazelaar; H. Greinix; B. Gritsch; Marie Trnkova; M. Vignetti; W. Arcese; R. Oneto; H. Ottinger; C. Müller; B. Kubanek; N. Schmitz; U. W. Schaefer; J. Passweg; H. Baldomero; K. Towlson; N. Russell; M. Arat; G. Gurman; N. Naya

doi:10.1038/sj.bmt.1705140

Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias: An EBMT analysis of lethal infectious complications and changes over calendar time

A. Gratwohl, R. Brand, F. Frassoni, V. Rocha, D. Niederwieser, P. Reusser, H. Einsele, C. Cordonnier, A. Urbano-Ispizua, A. Baur, P. Elvy, V. Chesnels, N. C. Gorin, P. Ljungman, C. Ruiz de Elvira, J. P. Jouet, A. Hagenbeek, Av Biezen, N. Tazelaar, H. GreinixB. Gritsch, Marie Trnkova, M. Vignetti, W. Arcese, R. Oneto, H. Ottinger, C. Müller, B. Kubanek, N. Schmitz, U. W. Schaefer, J. Passweg, H. Baldomero, K. Towlson, N. Russell, M. Arat, G. Gurman, N. Naya

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

We analysed a large homogeneous group of 14403 patients transplanted for early leukaemia from an HLA-identical sibling and reported to the EBMT in four time cohorts: 1980-1989 (24%), 1990-1994 (26%), 1995-1998 (30%) and 1999-2001 (20%). We focused on death from infection. End points were survival, death from relapse and transplant-related mortality (TRM), which was subdivided into death from graft-versus-host disease (GvHD) (1315 patients; 25% of deaths), infection (597 patients; 11% of deaths) or 'other' causes (1875 patients; 34% of deaths). Survival increased from 52% at 5 years in the first to 62% in the third cohort (P

Original language	English
Pages (from-to)	757-769
Number of pages	13
Journal	Bone Marrow Transplantation
Volume	36
Issue number	9
DOIs	https://doi.org/10.1038/sj.bmt.1705140
Publication status	Published - Nov 2005

Keywords

Cause of death
Change over time
Haematopoietic stem cell transplant
Infections
Transplant-related mortality

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/sj.bmt.1705140

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Gratwohl, A., Brand, R., Frassoni, F., Rocha, V., Niederwieser, D., Reusser, P., Einsele, H., Cordonnier, C., Urbano-Ispizua, A., Baur, A., Elvy, P., Chesnels, V., Gorin, N. C., Ljungman, P., Ruiz de Elvira, C., Jouet, J. P., Hagenbeek, A., Biezen, A., Tazelaar, N., ... Naya, N. (2005). Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias: An EBMT analysis of lethal infectious complications and changes over calendar time. Bone Marrow Transplantation, 36(9), 757-769. https://doi.org/10.1038/sj.bmt.1705140

Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias : An EBMT analysis of lethal infectious complications and changes over calendar time. / Gratwohl, A.; Brand, R.; Frassoni, F.; Rocha, V.; Niederwieser, D.; Reusser, P.; Einsele, H.; Cordonnier, C.; Urbano-Ispizua, A.; Baur, A.; Elvy, P.; Chesnels, V.; Gorin, N. C.; Ljungman, P.; Ruiz de Elvira, C.; Jouet, J. P.; Hagenbeek, A.; Biezen, Av; Tazelaar, N.; Greinix, H.; Gritsch, B.; Trnkova, Marie; Vignetti, M.; Arcese, W.; Oneto, R.; Ottinger, H.; Müller, C.; Kubanek, B.; Schmitz, N.; Schaefer, U. W.; Passweg, J.; Baldomero, H.; Towlson, K.; Russell, N.; Arat, M.; Gurman, G.; Naya, N.

In: Bone Marrow Transplantation, Vol. 36, No. 9, 11.2005, p. 757-769.

Research output: Contribution to journal › Article › peer-review

Gratwohl, A, Brand, R, Frassoni, F, Rocha, V, Niederwieser, D, Reusser, P, Einsele, H, Cordonnier, C, Urbano-Ispizua, A, Baur, A, Elvy, P, Chesnels, V, Gorin, NC, Ljungman, P, Ruiz de Elvira, C, Jouet, JP, Hagenbeek, A, Biezen, A, Tazelaar, N, Greinix, H, Gritsch, B, Trnkova, M, Vignetti, M, Arcese, W, Oneto, R, Ottinger, H, Müller, C, Kubanek, B, Schmitz, N, Schaefer, UW, Passweg, J, Baldomero, H, Towlson, K, Russell, N, Arat, M, Gurman, G & Naya, N 2005, 'Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias: An EBMT analysis of lethal infectious complications and changes over calendar time', Bone Marrow Transplantation, vol. 36, no. 9, pp. 757-769. https://doi.org/10.1038/sj.bmt.1705140

Gratwohl, A. ; Brand, R. ; Frassoni, F. ; Rocha, V. ; Niederwieser, D. ; Reusser, P. ; Einsele, H. ; Cordonnier, C. ; Urbano-Ispizua, A. ; Baur, A. ; Elvy, P. ; Chesnels, V. ; Gorin, N. C. ; Ljungman, P. ; Ruiz de Elvira, C. ; Jouet, J. P. ; Hagenbeek, A. ; Biezen, Av ; Tazelaar, N. ; Greinix, H. ; Gritsch, B. ; Trnkova, Marie ; Vignetti, M. ; Arcese, W. ; Oneto, R. ; Ottinger, H. ; Müller, C. ; Kubanek, B. ; Schmitz, N. ; Schaefer, U. W. ; Passweg, J. ; Baldomero, H. ; Towlson, K. ; Russell, N. ; Arat, M. ; Gurman, G. ; Naya, N. / Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias : An EBMT analysis of lethal infectious complications and changes over calendar time. In: Bone Marrow Transplantation. 2005 ; Vol. 36, No. 9. pp. 757-769.

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abstract = "We analysed a large homogeneous group of 14403 patients transplanted for early leukaemia from an HLA-identical sibling and reported to the EBMT in four time cohorts: 1980-1989 (24%), 1990-1994 (26%), 1995-1998 (30%) and 1999-2001 (20%). We focused on death from infection. End points were survival, death from relapse and transplant-related mortality (TRM), which was subdivided into death from graft-versus-host disease (GvHD) (1315 patients; 25% of deaths), infection (597 patients; 11% of deaths) or 'other' causes (1875 patients; 34% of deaths). Survival increased from 52% at 5 years in the first to 62% in the third cohort (P",

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T2 - An EBMT analysis of lethal infectious complications and changes over calendar time

AU - Gratwohl, A.

AU - Brand, R.

AU - Frassoni, F.

AU - Rocha, V.

AU - Niederwieser, D.

AU - Reusser, P.

AU - Einsele, H.

AU - Cordonnier, C.

AU - Urbano-Ispizua, A.

AU - Baur, A.

AU - Elvy, P.

AU - Chesnels, V.

AU - Gorin, N. C.

AU - Ljungman, P.

AU - Ruiz de Elvira, C.

AU - Jouet, J. P.

AU - Hagenbeek, A.

AU - Biezen, Av

AU - Tazelaar, N.

AU - Greinix, H.

AU - Gritsch, B.

AU - Trnkova, Marie

AU - Vignetti, M.

AU - Arcese, W.

AU - Oneto, R.

AU - Ottinger, H.

AU - Müller, C.

AU - Kubanek, B.

AU - Schmitz, N.

AU - Schaefer, U. W.

AU - Passweg, J.

AU - Baldomero, H.

AU - Towlson, K.

AU - Russell, N.

AU - Arat, M.

AU - Gurman, G.

AU - Naya, N.

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Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias: An EBMT analysis of lethal infectious complications and changes over calendar time

Abstract

Keywords

ASJC Scopus subject areas

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