Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias: An EBMT analysis of lethal infectious complications and changes over calendar time

A. Gratwohl, R. Brand, F. Frassoni, V. Rocha, D. Niederwieser, P. Reusser, H. Einsele, C. Cordonnier, A. Urbano-Ispizua, A. Baur, P. Elvy, V. Chesnels, N. C. Gorin, P. Ljungman, C. Ruiz de Elvira, J. P. Jouet, A. Hagenbeek, Av Biezen, N. Tazelaar, H. GreinixB. Gritsch, Marie Trnkova, M. Vignetti, W. Arcese, R. Oneto, H. Ottinger, C. Müller, B. Kubanek, N. Schmitz, U. W. Schaefer, J. Passweg, H. Baldomero, K. Towlson, N. Russell, M. Arat, G. Gurman, N. Naya

Research output: Contribution to journalArticlepeer-review

Abstract

We analysed a large homogeneous group of 14403 patients transplanted for early leukaemia from an HLA-identical sibling and reported to the EBMT in four time cohorts: 1980-1989 (24%), 1990-1994 (26%), 1995-1998 (30%) and 1999-2001 (20%). We focused on death from infection. End points were survival, death from relapse and transplant-related mortality (TRM), which was subdivided into death from graft-versus-host disease (GvHD) (1315 patients; 25% of deaths), infection (597 patients; 11% of deaths) or 'other' causes (1875 patients; 34% of deaths). Survival increased from 52% at 5 years in the first to 62% in the third cohort (P

Original languageEnglish
Pages (from-to)757-769
Number of pages13
JournalBone Marrow Transplantation
Volume36
Issue number9
DOIs
Publication statusPublished - Nov 2005

Keywords

  • Cause of death
  • Change over time
  • Haematopoietic stem cell transplant
  • Infections
  • Transplant-related mortality

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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