Abstract
We analysed a large homogeneous group of 14403 patients transplanted for early leukaemia from an HLA-identical sibling and reported to the EBMT in four time cohorts: 1980-1989 (24%), 1990-1994 (26%), 1995-1998 (30%) and 1999-2001 (20%). We focused on death from infection. End points were survival, death from relapse and transplant-related mortality (TRM), which was subdivided into death from graft-versus-host disease (GvHD) (1315 patients; 25% of deaths), infection (597 patients; 11% of deaths) or 'other' causes (1875 patients; 34% of deaths). Survival increased from 52% at 5 years in the first to 62% in the third cohort (P
Original language | English |
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Pages (from-to) | 757-769 |
Number of pages | 13 |
Journal | Bone Marrow Transplantation |
Volume | 36 |
Issue number | 9 |
DOIs | |
Publication status | Published - Nov 2005 |
Keywords
- Cause of death
- Change over time
- Haematopoietic stem cell transplant
- Infections
- Transplant-related mortality
ASJC Scopus subject areas
- Hematology
- Transplantation