TY - JOUR
T1 - Causes of Death Following PCI Versus CABG in Complex CAD 5-Year Follow-Up of SYNTAX
AU - Milojevic, Milan
AU - Head, Stuart J.
AU - Parasca, Catalina A.
AU - Serruys, Patrick W.
AU - Mohr, Friedrich W.
AU - Morice, Marie Claude
AU - Mack, Michael J.
AU - Ståhle, Elisabeth
AU - Feldman, Ted E.
AU - Dawkins, Keith D.
AU - Colombo, Antonio
AU - Kappetein, A. Pieter
AU - Holmes, David R.
PY - 2016/1/5
Y1 - 2016/1/5
N2 - Background There are no data available on specific causes of death from randomized trials that have compared coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI). Objectives The purpose of this study was to investigate specific causes of death, and its predictors, after revascularization for complex coronary disease in patients. Methods An independent Clinical Events Committee consisting of expert physicians who were blinded to the study treatment subclassified causes of death as cardiovascular (cardiac and vascular), noncardiovascular, or undetermined according to the trial protocol. Cardiac deaths were classified as sudden cardiac, related to myocardial infarction (MI), and other cardiac deaths. Results In the randomized cohort, there were 97 deaths after CABG and 123 deaths after PCI during a 5-year follow-up. After CABG, 49.4% of deaths were cardiovascular, with the greatest cause being heart failure, arrhythmia, or other causes (24.6%), whereas after PCI, the majority of deaths were cardiovascular (67.5%) and as a result of MI (29.3%). The cumulative incidence rates of all-cause death were not significantly different between CABG and PCI (11.4% vs. 13.9%, respectively; p = 0.10), whereas there were significant differences in terms of cardiovascular (5.8% vs. 9.6%, respectively; p = 0.008) and cardiac death (5.3% vs. 9.0%, respectively; p = 0.003), which were caused primarily by a reduction in MI-related death with CABG compared with PCI (0.4% vs. 4.1%, respectively; p
AB - Background There are no data available on specific causes of death from randomized trials that have compared coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI). Objectives The purpose of this study was to investigate specific causes of death, and its predictors, after revascularization for complex coronary disease in patients. Methods An independent Clinical Events Committee consisting of expert physicians who were blinded to the study treatment subclassified causes of death as cardiovascular (cardiac and vascular), noncardiovascular, or undetermined according to the trial protocol. Cardiac deaths were classified as sudden cardiac, related to myocardial infarction (MI), and other cardiac deaths. Results In the randomized cohort, there were 97 deaths after CABG and 123 deaths after PCI during a 5-year follow-up. After CABG, 49.4% of deaths were cardiovascular, with the greatest cause being heart failure, arrhythmia, or other causes (24.6%), whereas after PCI, the majority of deaths were cardiovascular (67.5%) and as a result of MI (29.3%). The cumulative incidence rates of all-cause death were not significantly different between CABG and PCI (11.4% vs. 13.9%, respectively; p = 0.10), whereas there were significant differences in terms of cardiovascular (5.8% vs. 9.6%, respectively; p = 0.008) and cardiac death (5.3% vs. 9.0%, respectively; p = 0.003), which were caused primarily by a reduction in MI-related death with CABG compared with PCI (0.4% vs. 4.1%, respectively; p
KW - cause of death
KW - coronary artery bypass grafting
KW - heart failure
KW - Key Words cardiac death
KW - myocardial infarction
KW - percutaneous coronary intervention
KW - stroke
KW - sudden death
KW - SYNTAX
UR - http://www.scopus.com/inward/record.url?scp=84952908312&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84952908312&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2015.10.043
DO - 10.1016/j.jacc.2015.10.043
M3 - Article
C2 - 26764065
AN - SCOPUS:84952908312
VL - 67
SP - 42
EP - 55
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 1
ER -