TY - JOUR
T1 - Causes of death in patients ≥75 years of age with non-ST-segment elevation acute coronary syndrome
AU - Morici, Nuccia
AU - Savonitto, Stefano
AU - Murena, Ernesto
AU - Antonicelli, Roberto
AU - Piovaccari, Giancarlo
AU - Tucci, Daniele
AU - Tamburino, Corrado
AU - Fontanelli, Alessandro
AU - Bolognese, Leonardo
AU - Menozzi, Mila
AU - Cavallini, Claudio
AU - Petronio, Anna Sonia
AU - Ambrosio, Giuseppe
AU - Piscione, Federico
AU - Steffenino, Giuseppe
AU - De Servi, Stefano
PY - 2013/7/1
Y1 - 2013/7/1
N2 - The causes of death within 1 year of hospital admission in patients with non-ST-segment elevation acute coronary syndromes are ill defined, particularly in patients aged ≥75 years. From January 2008 through May 2010, we enrolled 645 patients aged ≥75 years with non-ST-segment elevation acute coronary syndromes: 313 in a randomized trial comparing an early aggressive versus an initially conservative approach, and 332, excluded from the trial for specific reasons, in a parallel registry. Each death occurring during 1 year of follow-up was adjudicated by an independent committee. The mean age was 82 years in both study cohorts, and 53% were men. By the end of the follow-up period (median 369 days, interquartile range 345 to 391), 120 patients (18.6%) had died. The mortality was significantly greater in the registry (23.8% vs 13.1%, p = 0.001). The deaths were classified as cardiac in 94% of the cases during the index admission and 68% of the cases during the follow-up period. Eighty-six percent of the cardiac deaths were of ischemic origin. In a multivariate logistic regression model that included the variables present on admission in the whole study population, the ejection fraction (hazard ratio 0.95, 95% confidence interval 0.94 to 0.97; p
AB - The causes of death within 1 year of hospital admission in patients with non-ST-segment elevation acute coronary syndromes are ill defined, particularly in patients aged ≥75 years. From January 2008 through May 2010, we enrolled 645 patients aged ≥75 years with non-ST-segment elevation acute coronary syndromes: 313 in a randomized trial comparing an early aggressive versus an initially conservative approach, and 332, excluded from the trial for specific reasons, in a parallel registry. Each death occurring during 1 year of follow-up was adjudicated by an independent committee. The mean age was 82 years in both study cohorts, and 53% were men. By the end of the follow-up period (median 369 days, interquartile range 345 to 391), 120 patients (18.6%) had died. The mortality was significantly greater in the registry (23.8% vs 13.1%, p = 0.001). The deaths were classified as cardiac in 94% of the cases during the index admission and 68% of the cases during the follow-up period. Eighty-six percent of the cardiac deaths were of ischemic origin. In a multivariate logistic regression model that included the variables present on admission in the whole study population, the ejection fraction (hazard ratio 0.95, 95% confidence interval 0.94 to 0.97; p
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U2 - 10.1016/j.amjcard.2013.02.043
DO - 10.1016/j.amjcard.2013.02.043
M3 - Article
C2 - 23540546
AN - SCOPUS:84879073242
VL - 112
SP - 1
EP - 7
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 1
ER -