Causes of death in patients ≥75 years of age with non-ST-segment elevation acute coronary syndrome

Nuccia Morici, Stefano Savonitto, Ernesto Murena, Roberto Antonicelli, Giancarlo Piovaccari, Daniele Tucci, Corrado Tamburino, Alessandro Fontanelli, Leonardo Bolognese, Mila Menozzi, Claudio Cavallini, Anna Sonia Petronio, Giuseppe Ambrosio, Federico Piscione, Giuseppe Steffenino, Stefano De Servi

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The causes of death within 1 year of hospital admission in patients with non-ST-segment elevation acute coronary syndromes are ill defined, particularly in patients aged ≥75 years. From January 2008 through May 2010, we enrolled 645 patients aged ≥75 years with non-ST-segment elevation acute coronary syndromes: 313 in a randomized trial comparing an early aggressive versus an initially conservative approach, and 332, excluded from the trial for specific reasons, in a parallel registry. Each death occurring during 1 year of follow-up was adjudicated by an independent committee. The mean age was 82 years in both study cohorts, and 53% were men. By the end of the follow-up period (median 369 days, interquartile range 345 to 391), 120 patients (18.6%) had died. The mortality was significantly greater in the registry (23.8% vs 13.1%, p = 0.001). The deaths were classified as cardiac in 94% of the cases during the index admission and 68% of the cases during the follow-up period. Eighty-six percent of the cardiac deaths were of ischemic origin. In a multivariate logistic regression model that included the variables present on admission in the whole study population, the ejection fraction (hazard ratio 0.95, 95% confidence interval 0.94 to 0.97; p

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalThe American Journal of Cardiology
Issue number1
Publication statusPublished - Jul 1 2013

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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