Abstract
The causes of death within 1 year of hospital admission in patients with non-ST-segment elevation acute coronary syndromes are ill defined, particularly in patients aged ≥75 years. From January 2008 through May 2010, we enrolled 645 patients aged ≥75 years with non-ST-segment elevation acute coronary syndromes: 313 in a randomized trial comparing an early aggressive versus an initially conservative approach, and 332, excluded from the trial for specific reasons, in a parallel registry. Each death occurring during 1 year of follow-up was adjudicated by an independent committee. The mean age was 82 years in both study cohorts, and 53% were men. By the end of the follow-up period (median 369 days, interquartile range 345 to 391), 120 patients (18.6%) had died. The mortality was significantly greater in the registry (23.8% vs 13.1%, p = 0.001). The deaths were classified as cardiac in 94% of the cases during the index admission and 68% of the cases during the follow-up period. Eighty-six percent of the cardiac deaths were of ischemic origin. In a multivariate logistic regression model that included the variables present on admission in the whole study population, the ejection fraction (hazard ratio 0.95, 95% confidence interval 0.94 to 0.97; p
| Original language | English |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | The American Journal of Cardiology |
| Volume | 112 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 1 2013 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Causes of death in patients ≥75 years of age with non-ST-segment elevation acute coronary syndrome. / Morici, Nuccia; Savonitto, Stefano; Murena, Ernesto; Antonicelli, Roberto; Piovaccari, Giancarlo; Tucci, Daniele; Tamburino, Corrado; Fontanelli, Alessandro; Bolognese, Leonardo; Menozzi, Mila; Cavallini, Claudio; Petronio, Anna Sonia; Ambrosio, Giuseppe; Piscione, Federico; Steffenino, Giuseppe; De Servi, Stefano.
In: The American Journal of Cardiology, Vol. 112, No. 1, 01.07.2013, p. 1-7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Causes of death in patients ≥75 years of age with non-ST-segment elevation acute coronary syndrome
AU - Morici, Nuccia
AU - Savonitto, Stefano
AU - Murena, Ernesto
AU - Antonicelli, Roberto
AU - Piovaccari, Giancarlo
AU - Tucci, Daniele
AU - Tamburino, Corrado
AU - Fontanelli, Alessandro
AU - Bolognese, Leonardo
AU - Menozzi, Mila
AU - Cavallini, Claudio
AU - Petronio, Anna Sonia
AU - Ambrosio, Giuseppe
AU - Piscione, Federico
AU - Steffenino, Giuseppe
AU - De Servi, Stefano
PY - 2013/7/1
Y1 - 2013/7/1
N2 - The causes of death within 1 year of hospital admission in patients with non-ST-segment elevation acute coronary syndromes are ill defined, particularly in patients aged ≥75 years. From January 2008 through May 2010, we enrolled 645 patients aged ≥75 years with non-ST-segment elevation acute coronary syndromes: 313 in a randomized trial comparing an early aggressive versus an initially conservative approach, and 332, excluded from the trial for specific reasons, in a parallel registry. Each death occurring during 1 year of follow-up was adjudicated by an independent committee. The mean age was 82 years in both study cohorts, and 53% were men. By the end of the follow-up period (median 369 days, interquartile range 345 to 391), 120 patients (18.6%) had died. The mortality was significantly greater in the registry (23.8% vs 13.1%, p = 0.001). The deaths were classified as cardiac in 94% of the cases during the index admission and 68% of the cases during the follow-up period. Eighty-six percent of the cardiac deaths were of ischemic origin. In a multivariate logistic regression model that included the variables present on admission in the whole study population, the ejection fraction (hazard ratio 0.95, 95% confidence interval 0.94 to 0.97; p
AB - The causes of death within 1 year of hospital admission in patients with non-ST-segment elevation acute coronary syndromes are ill defined, particularly in patients aged ≥75 years. From January 2008 through May 2010, we enrolled 645 patients aged ≥75 years with non-ST-segment elevation acute coronary syndromes: 313 in a randomized trial comparing an early aggressive versus an initially conservative approach, and 332, excluded from the trial for specific reasons, in a parallel registry. Each death occurring during 1 year of follow-up was adjudicated by an independent committee. The mean age was 82 years in both study cohorts, and 53% were men. By the end of the follow-up period (median 369 days, interquartile range 345 to 391), 120 patients (18.6%) had died. The mortality was significantly greater in the registry (23.8% vs 13.1%, p = 0.001). The deaths were classified as cardiac in 94% of the cases during the index admission and 68% of the cases during the follow-up period. Eighty-six percent of the cardiac deaths were of ischemic origin. In a multivariate logistic regression model that included the variables present on admission in the whole study population, the ejection fraction (hazard ratio 0.95, 95% confidence interval 0.94 to 0.97; p
UR - http://www.scopus.com/inward/record.url?scp=84879073242&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879073242&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2013.02.043
DO - 10.1016/j.amjcard.2013.02.043
M3 - Article
C2 - 23540546
AN - SCOPUS:84879073242
VL - 112
SP - 1
EP - 7
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 1
ER -