Causes of late failure after heart transplantation

A ten-year survey

P. Gallo, L. Agozzino, A. Angelini, E. Arbustini, G. Bartoloni, P. Bernucci, E. Bonacina, C. Bosman, G. Catani, C. Di Gioia, C. Giordana, O. Leone, T. Motta, A. Pucci, M. Rocco

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Background: Little is known about the causes of death of heart transplant recipients who survive long-term. Methods: The pathologic and clinical records of 97 patients who underwent heart transplantation in Italy from 1985 to 1995 and died (85 of 97) or underwent retransplantation (12 of 97) at least 2 years after transplantation were surveyed. Graft failures were classified as late (occurring between 2 and 5 years after transplantation) and belated (more than 5 years). Results: Graft vasculopathy was the single most common cause of death (40.0%) and the only cause of late retransplantation. Tumors ranked second (23.5% of deaths), but the expected non-Hodgkin's lymphomas and Kaposi's sarcoma were accompanied by a high number of lung cancers (especially metastasizing adenocarcinomas). They were followed by the emergence or recurrence of pretransplantation diseases (9.4%), fatal infections (exclusively bacterial) (4.7%), the development of transmissible diseases (viral hepatitis and acquired immunodeficiency syndrome, 4.7%), and late acute rejection (2.3%). The distribution of failures differed in the late and belated periods: death and organ loss proportions for graft vasculopathy, respectively, fell and rose from the late to the belated period; some types of malignancy and fatal acute rejection were never observed in the belated period, whereas the emergence of pretransplantation diseases prevailed in the belated period. Graft vasculopathy was more frequent and tumors were less frequent among patients undergoing transplantation for ischemic heart disease. Conclusions: The reasons why heart transplant recipients die or undergo retransplantation, respectively, in the late and belated periods slightly differ from one another and are widely different than in short-term survivors.

Original languageEnglish
Pages (from-to)1113-1121
Number of pages9
JournalJournal of Heart and Lung Transplantation
Volume16
Issue number11
Publication statusPublished - 1997

Fingerprint

Heart Transplantation
Transplants
Transplantation
Cause of Death
Neoplasms
Kaposi's Sarcoma
Virus Diseases
Bacterial Infections
Non-Hodgkin's Lymphoma
Italy
Hepatitis
Myocardial Ischemia
Survivors
Lung Neoplasms
Acquired Immunodeficiency Syndrome
Adenocarcinoma
Recurrence
Surveys and Questionnaires
Transplant Recipients

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Transplantation

Cite this

Gallo, P., Agozzino, L., Angelini, A., Arbustini, E., Bartoloni, G., Bernucci, P., ... Rocco, M. (1997). Causes of late failure after heart transplantation: A ten-year survey. Journal of Heart and Lung Transplantation, 16(11), 1113-1121.

Causes of late failure after heart transplantation : A ten-year survey. / Gallo, P.; Agozzino, L.; Angelini, A.; Arbustini, E.; Bartoloni, G.; Bernucci, P.; Bonacina, E.; Bosman, C.; Catani, G.; Di Gioia, C.; Giordana, C.; Leone, O.; Motta, T.; Pucci, A.; Rocco, M.

In: Journal of Heart and Lung Transplantation, Vol. 16, No. 11, 1997, p. 1113-1121.

Research output: Contribution to journalArticle

Gallo, P, Agozzino, L, Angelini, A, Arbustini, E, Bartoloni, G, Bernucci, P, Bonacina, E, Bosman, C, Catani, G, Di Gioia, C, Giordana, C, Leone, O, Motta, T, Pucci, A & Rocco, M 1997, 'Causes of late failure after heart transplantation: A ten-year survey', Journal of Heart and Lung Transplantation, vol. 16, no. 11, pp. 1113-1121.
Gallo P, Agozzino L, Angelini A, Arbustini E, Bartoloni G, Bernucci P et al. Causes of late failure after heart transplantation: A ten-year survey. Journal of Heart and Lung Transplantation. 1997;16(11):1113-1121.
Gallo, P. ; Agozzino, L. ; Angelini, A. ; Arbustini, E. ; Bartoloni, G. ; Bernucci, P. ; Bonacina, E. ; Bosman, C. ; Catani, G. ; Di Gioia, C. ; Giordana, C. ; Leone, O. ; Motta, T. ; Pucci, A. ; Rocco, M. / Causes of late failure after heart transplantation : A ten-year survey. In: Journal of Heart and Lung Transplantation. 1997 ; Vol. 16, No. 11. pp. 1113-1121.
@article{15a07c4fab3c44889661471097529a10,
title = "Causes of late failure after heart transplantation: A ten-year survey",
abstract = "Background: Little is known about the causes of death of heart transplant recipients who survive long-term. Methods: The pathologic and clinical records of 97 patients who underwent heart transplantation in Italy from 1985 to 1995 and died (85 of 97) or underwent retransplantation (12 of 97) at least 2 years after transplantation were surveyed. Graft failures were classified as late (occurring between 2 and 5 years after transplantation) and belated (more than 5 years). Results: Graft vasculopathy was the single most common cause of death (40.0{\%}) and the only cause of late retransplantation. Tumors ranked second (23.5{\%} of deaths), but the expected non-Hodgkin's lymphomas and Kaposi's sarcoma were accompanied by a high number of lung cancers (especially metastasizing adenocarcinomas). They were followed by the emergence or recurrence of pretransplantation diseases (9.4{\%}), fatal infections (exclusively bacterial) (4.7{\%}), the development of transmissible diseases (viral hepatitis and acquired immunodeficiency syndrome, 4.7{\%}), and late acute rejection (2.3{\%}). The distribution of failures differed in the late and belated periods: death and organ loss proportions for graft vasculopathy, respectively, fell and rose from the late to the belated period; some types of malignancy and fatal acute rejection were never observed in the belated period, whereas the emergence of pretransplantation diseases prevailed in the belated period. Graft vasculopathy was more frequent and tumors were less frequent among patients undergoing transplantation for ischemic heart disease. Conclusions: The reasons why heart transplant recipients die or undergo retransplantation, respectively, in the late and belated periods slightly differ from one another and are widely different than in short-term survivors.",
author = "P. Gallo and L. Agozzino and A. Angelini and E. Arbustini and G. Bartoloni and P. Bernucci and E. Bonacina and C. Bosman and G. Catani and {Di Gioia}, C. and C. Giordana and O. Leone and T. Motta and A. Pucci and M. Rocco",
year = "1997",
language = "English",
volume = "16",
pages = "1113--1121",
journal = "Journal of Heart and Lung Transplantation",
issn = "1053-2498",
publisher = "Elsevier USA",
number = "11",

}

TY - JOUR

T1 - Causes of late failure after heart transplantation

T2 - A ten-year survey

AU - Gallo, P.

AU - Agozzino, L.

AU - Angelini, A.

AU - Arbustini, E.

AU - Bartoloni, G.

AU - Bernucci, P.

AU - Bonacina, E.

AU - Bosman, C.

AU - Catani, G.

AU - Di Gioia, C.

AU - Giordana, C.

AU - Leone, O.

AU - Motta, T.

AU - Pucci, A.

AU - Rocco, M.

PY - 1997

Y1 - 1997

N2 - Background: Little is known about the causes of death of heart transplant recipients who survive long-term. Methods: The pathologic and clinical records of 97 patients who underwent heart transplantation in Italy from 1985 to 1995 and died (85 of 97) or underwent retransplantation (12 of 97) at least 2 years after transplantation were surveyed. Graft failures were classified as late (occurring between 2 and 5 years after transplantation) and belated (more than 5 years). Results: Graft vasculopathy was the single most common cause of death (40.0%) and the only cause of late retransplantation. Tumors ranked second (23.5% of deaths), but the expected non-Hodgkin's lymphomas and Kaposi's sarcoma were accompanied by a high number of lung cancers (especially metastasizing adenocarcinomas). They were followed by the emergence or recurrence of pretransplantation diseases (9.4%), fatal infections (exclusively bacterial) (4.7%), the development of transmissible diseases (viral hepatitis and acquired immunodeficiency syndrome, 4.7%), and late acute rejection (2.3%). The distribution of failures differed in the late and belated periods: death and organ loss proportions for graft vasculopathy, respectively, fell and rose from the late to the belated period; some types of malignancy and fatal acute rejection were never observed in the belated period, whereas the emergence of pretransplantation diseases prevailed in the belated period. Graft vasculopathy was more frequent and tumors were less frequent among patients undergoing transplantation for ischemic heart disease. Conclusions: The reasons why heart transplant recipients die or undergo retransplantation, respectively, in the late and belated periods slightly differ from one another and are widely different than in short-term survivors.

AB - Background: Little is known about the causes of death of heart transplant recipients who survive long-term. Methods: The pathologic and clinical records of 97 patients who underwent heart transplantation in Italy from 1985 to 1995 and died (85 of 97) or underwent retransplantation (12 of 97) at least 2 years after transplantation were surveyed. Graft failures were classified as late (occurring between 2 and 5 years after transplantation) and belated (more than 5 years). Results: Graft vasculopathy was the single most common cause of death (40.0%) and the only cause of late retransplantation. Tumors ranked second (23.5% of deaths), but the expected non-Hodgkin's lymphomas and Kaposi's sarcoma were accompanied by a high number of lung cancers (especially metastasizing adenocarcinomas). They were followed by the emergence or recurrence of pretransplantation diseases (9.4%), fatal infections (exclusively bacterial) (4.7%), the development of transmissible diseases (viral hepatitis and acquired immunodeficiency syndrome, 4.7%), and late acute rejection (2.3%). The distribution of failures differed in the late and belated periods: death and organ loss proportions for graft vasculopathy, respectively, fell and rose from the late to the belated period; some types of malignancy and fatal acute rejection were never observed in the belated period, whereas the emergence of pretransplantation diseases prevailed in the belated period. Graft vasculopathy was more frequent and tumors were less frequent among patients undergoing transplantation for ischemic heart disease. Conclusions: The reasons why heart transplant recipients die or undergo retransplantation, respectively, in the late and belated periods slightly differ from one another and are widely different than in short-term survivors.

UR - http://www.scopus.com/inward/record.url?scp=0030712371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030712371&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 1113

EP - 1121

JO - Journal of Heart and Lung Transplantation

JF - Journal of Heart and Lung Transplantation

SN - 1053-2498

IS - 11

ER -