Abstract
Caveolae are non-clathrin invaginations of the plasma membrane in most cell types; they are involved in signalling functions and molecule trafficking, thus modulating several biological functions, including cell growth, apoptosis and angiogenesis. The major structural protein in caveolae is caveolin-1, which is known to act as a key regulator in cancer onset and progression through its role as a tumour suppressor. Caveolin-1 can also promote cell proliferation, survival and metastasis as well as chemo- and radioresistance. Here, we discuss recent findings and novel concepts that support a role for caveolin-1 in cancer development and its distant spreading. We also address the potential application of caveolin-1 in tumour therapy and diagnosis.
Original language | English |
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Pages (from-to) | 325-336 |
Number of pages | 12 |
Journal | Journal of Cellular and Molecular Medicine |
Volume | 17 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2013 |
Keywords
- Biomarkers
- Cancer
- Caveolin-1
- Metastases
- Targeted therapy
ASJC Scopus subject areas
- Cell Biology
- Molecular Medicine