Caveolin-1 as a promoter of tumour spreading: When, how, where and why

Rebecca Senetta, Giulia Stella, Ernesto Pozzi, Niccolo Sturli, Daniela Massi, Paola Cassoni

Research output: Contribution to journalArticlepeer-review

Abstract

Caveolae are non-clathrin invaginations of the plasma membrane in most cell types; they are involved in signalling functions and molecule trafficking, thus modulating several biological functions, including cell growth, apoptosis and angiogenesis. The major structural protein in caveolae is caveolin-1, which is known to act as a key regulator in cancer onset and progression through its role as a tumour suppressor. Caveolin-1 can also promote cell proliferation, survival and metastasis as well as chemo- and radioresistance. Here, we discuss recent findings and novel concepts that support a role for caveolin-1 in cancer development and its distant spreading. We also address the potential application of caveolin-1 in tumour therapy and diagnosis.

Original languageEnglish
Pages (from-to)325-336
Number of pages12
JournalJournal of Cellular and Molecular Medicine
Volume17
Issue number3
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Biomarkers
  • Cancer
  • Caveolin-1
  • Metastases
  • Targeted therapy

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine

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