CAVEOLIN-1 expression in brain metastasis from lung cancer predicts worse outcome and radioresistance, irrespective of tumor histotype

Eleonora Duregon, Rebecca Senetta, Alessandra Pittaro, Ludovica Verdun Di Cantogno, Giulia Stella, Pierpaolo De Blasi, Michele Zorzetto, Cristina Mantovani, Mauro Papotti, Paola Cassoni

Research output: Contribution to journalArticlepeer-review

Abstract

Brain metastases develop in one-third of patients with non-small-cell lung cancer and are associated with a dismal prognosis, irrespective of surgery or chemo-radiotherapy. Pathological markers for predicting outcomes after surgical resection and radiotherapy responsiveness are still lacking. Caveolin 1 has been associated with chemo- and radioresistance in various tumors, including non-small-cell lung cancer. Here, caveolin 1 expression was assessed in a series of 69 brain metastases from non-small-cell lung cancer and matched primary tumors to determine its role in predicting survival and radiotherapy responsiveness. Only caveolin 1 expression in brain metastasis was associated with poor prognosis and an increased risk of death (log rank test, p = 0.015). Moreover, in the younger patients (median age of

Original languageEnglish
Pages (from-to)29626-29636
Number of pages11
JournalOncotarget
Volume6
Issue number30
DOIs
Publication statusPublished - 2015

Keywords

  • Brain metastasis
  • Caveolin 1
  • Non-small-cell lung cancer
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology

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