CBX7 expression in oncocytic thyroid neoplastic lesions (Hürthle cell adenomas and carcinomas)

Mario Monaco, Gennaro Chiappetta, Concetta Aiello, Antonella Federico, Romina Sepe, Daniela Russo, Alfredo Fusco, Pierlorenzo Pallante

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Previous analysis of CBX7 expression in a large number of thyroid adenoma and carcinoma samples revealed a progressive reduction of CBX7 levels that was well related with the malignant grade of thyroid neoplasias. Hürthle cell tumors are unusual thyroid neoplasms characterized by the presence of particular cells called oncocytes. Objectives: In order to develop new tools for a more accurate diagnosis of Hürthle cell tumors of the thyroid, we evaluated CBX7 protein levels to verify the possible presence of an expression signature. Methods: CBX7 expression was evaluated by immunohistochemistry in a panel of thyroid tissue sections including normal thyroids, goiters, follicular adenomas and oncocytic lesions. Results: CBX7 expression was low or null in 68% of Hürthle adenomas, whereas it was comparable to normal thyroid tissue in Hürthle hyperplasias and follicular adenomas. Conclusions: Reduced expression of CBX7 suggests a more aggressive identity of Hürthle adenomas with respect to non-Hürthle ones.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalEuropean Thyroid Journal
Volume3
Issue number4
DOIs
Publication statusPublished - Dec 25 2014

Keywords

  • CBX7
  • Hürthle cell
  • Oncocytic lesions
  • Thyroid

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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