CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis

Giulia Pazzola, Luigi Boiardi, Bruno Casali, Enrico Farnetti, Davide Nicoli, Nicolò Pipitone, Ilaria Padovano, Andrea Caruso, Mariagrazia Catanoso, Carlo Salvarani

Research output: Contribution to journalArticlepeer-review

Abstract

Abstracts: Objectives: To evaluate the potential role of CC chemokine receptor 5 (CCR5)Δ32 polymorphism in the susceptibility to giant cell arteritis (GCA) in a cohort of Italian patients. Methods: 176 consecutive Italian patients with biopsy-proven GCA and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5Δ32 polymorphism. Results: No statistically significant difference in the Δ32CCR5 allele frequency between GCA patients (5.1 %) and controls (2.8 %) was observed (p = 0.109). Carriers of the CCR5Δ32 allele (Δ32/Δ32 + CCR5/Δ32) were similarly represented in the two groups. Conclusions: Our results do not support a role for the CCR5Δ32 polymorphism in determining susceptibility to GCA.

Original languageEnglish
Pages (from-to)851-855
Number of pages5
JournalModern Rheumatology
Volume23
Issue number5
DOIs
Publication statusPublished - Sep 2013

Keywords

  • CC chemokine receptor 5 Δ32 polymorphism
  • Giant cell arteritis

ASJC Scopus subject areas

  • Rheumatology

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