Abstract
Abstracts: Objectives: To evaluate the potential role of CC chemokine receptor 5 (CCR5)Δ32 polymorphism in the susceptibility to giant cell arteritis (GCA) in a cohort of Italian patients. Methods: 176 consecutive Italian patients with biopsy-proven GCA and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5Δ32 polymorphism. Results: No statistically significant difference in the Δ32CCR5 allele frequency between GCA patients (5.1 %) and controls (2.8 %) was observed (p = 0.109). Carriers of the CCR5Δ32 allele (Δ32/Δ32 + CCR5/Δ32) were similarly represented in the two groups. Conclusions: Our results do not support a role for the CCR5Δ32 polymorphism in determining susceptibility to GCA.
Original language | English |
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Pages (from-to) | 851-855 |
Number of pages | 5 |
Journal | Modern Rheumatology |
Volume | 23 |
Issue number | 5 |
DOIs | |
Publication status | Published - Sep 2013 |
Keywords
- CC chemokine receptor 5 Δ32 polymorphism
- Giant cell arteritis
ASJC Scopus subject areas
- Rheumatology