CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis

Giulia Pazzola; Luigi Boiardi; Bruno Casali; Enrico Farnetti; Davide Nicoli; Nicolò Pipitone; Ilaria Padovano; Andrea Caruso; Mariagrazia Catanoso; Carlo Salvarani

doi:10.1007/s10165-012-0751-5

CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis

Giulia Pazzola, Luigi Boiardi, Bruno Casali, Enrico Farnetti, Davide Nicoli, Nicolò Pipitone, Ilaria Padovano, Andrea Caruso, Mariagrazia Catanoso, Carlo Salvarani

Arcispedale Santa Maria Nuova

Research output: Contribution to journal › Article › peer-review

Abstract

Abstracts: Objectives: To evaluate the potential role of CC chemokine receptor 5 (CCR5)Δ32 polymorphism in the susceptibility to giant cell arteritis (GCA) in a cohort of Italian patients. Methods: 176 consecutive Italian patients with biopsy-proven GCA and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5Δ32 polymorphism. Results: No statistically significant difference in the Δ32CCR5 allele frequency between GCA patients (5.1 %) and controls (2.8 %) was observed (p = 0.109). Carriers of the CCR5Δ32 allele (Δ32/Δ32 + CCR5/Δ32) were similarly represented in the two groups. Conclusions: Our results do not support a role for the CCR5Δ32 polymorphism in determining susceptibility to GCA.

Original language	English
Pages (from-to)	851-855
Number of pages	5
Journal	Modern Rheumatology
Volume	23
Issue number	5
DOIs	https://doi.org/10.1007/s10165-012-0751-5
Publication status	Published - Sep 2013

Keywords

CC chemokine receptor 5 Δ32 polymorphism
Giant cell arteritis

ASJC Scopus subject areas

Rheumatology

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10.1007/s10165-012-0751-5

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CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis. / Pazzola, Giulia; Boiardi, Luigi; Casali, Bruno; Farnetti, Enrico; Nicoli, Davide; Pipitone, Nicolò; Padovano, Ilaria; Caruso, Andrea; Catanoso, Mariagrazia; Salvarani, Carlo.

In: Modern Rheumatology, Vol. 23, No. 5, 09.2013, p. 851-855.

Research output: Contribution to journal › Article › peer-review

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title = "CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis",

abstract = "Abstracts: Objectives: To evaluate the potential role of CC chemokine receptor 5 (CCR5)Δ32 polymorphism in the susceptibility to giant cell arteritis (GCA) in a cohort of Italian patients. Methods: 176 consecutive Italian patients with biopsy-proven GCA and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5Δ32 polymorphism. Results: No statistically significant difference in the Δ32CCR5 allele frequency between GCA patients (5.1 %) and controls (2.8 %) was observed (p = 0.109). Carriers of the CCR5Δ32 allele (Δ32/Δ32 + CCR5/Δ32) were similarly represented in the two groups. Conclusions: Our results do not support a role for the CCR5Δ32 polymorphism in determining susceptibility to GCA.",

keywords = "CC chemokine receptor 5 Δ32 polymorphism, Giant cell arteritis",

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AU - Pazzola, Giulia

AU - Boiardi, Luigi

AU - Casali, Bruno

AU - Farnetti, Enrico

AU - Nicoli, Davide

AU - Pipitone, Nicolò

AU - Padovano, Ilaria

AU - Caruso, Andrea

AU - Catanoso, Mariagrazia

AU - Salvarani, Carlo

PY - 2013/9

Y1 - 2013/9

N2 - Abstracts: Objectives: To evaluate the potential role of CC chemokine receptor 5 (CCR5)Δ32 polymorphism in the susceptibility to giant cell arteritis (GCA) in a cohort of Italian patients. Methods: 176 consecutive Italian patients with biopsy-proven GCA and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5Δ32 polymorphism. Results: No statistically significant difference in the Δ32CCR5 allele frequency between GCA patients (5.1 %) and controls (2.8 %) was observed (p = 0.109). Carriers of the CCR5Δ32 allele (Δ32/Δ32 + CCR5/Δ32) were similarly represented in the two groups. Conclusions: Our results do not support a role for the CCR5Δ32 polymorphism in determining susceptibility to GCA.

AB - Abstracts: Objectives: To evaluate the potential role of CC chemokine receptor 5 (CCR5)Δ32 polymorphism in the susceptibility to giant cell arteritis (GCA) in a cohort of Italian patients. Methods: 176 consecutive Italian patients with biopsy-proven GCA and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5Δ32 polymorphism. Results: No statistically significant difference in the Δ32CCR5 allele frequency between GCA patients (5.1 %) and controls (2.8 %) was observed (p = 0.109). Carriers of the CCR5Δ32 allele (Δ32/Δ32 + CCR5/Δ32) were similarly represented in the two groups. Conclusions: Our results do not support a role for the CCR5Δ32 polymorphism in determining susceptibility to GCA.

KW - CC chemokine receptor 5 Δ32 polymorphism

KW - Giant cell arteritis

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CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis

Abstract

Keywords

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