Abstract
This chapter focuses on CC chemokines, which are a complex system of molecules that affect a variety of hematopoietic and non-hematopoietic cell types. Validation as pharmacological targets includes gene targeting, usage of antibodies or antagonists, whose expression in human pathology is discussed in the chapter. CC chemokine receptor antagonists have been developed, and are at various stages of preclinical or clinical development. CC chemokines are the most numerous, and diversified family of the four subgroups defined, based on the Cys motif (CC, CXC, C, CX3C). In humans, it includes at least 25 members interacting with at least 11 signaling receptors. CC chemokines have been discovered following different pathways, ranging from biological, and biochemical identification to direct cDNA cloning to, more recently, in silico cloning by gene bank mining. The development of efficacious CC chemokine antagonists remains a "holy grail" for the general field of cytokine pharmacology. The chemokines role in the transition from innate to acquired immunity, and in amplification of polarized responses on selected molecules, and pathologies are used as a paradigm.
| Original language | English |
|---|---|
| Title of host publication | The Cytokine Handbook |
| Publisher | Elsevier Inc. |
| Pages | 1083-1100 |
| Number of pages | 18 |
| ISBN (Print) | 9780080518794, 9780126896633 |
| DOIs | |
| Publication status | Published - Jul 7 2003 |
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ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)
Cite this
CC chemokines. / Mantovani, Alberto; Locati, Massimo; Sozzani, Silvano.
The Cytokine Handbook. Elsevier Inc., 2003. p. 1083-1100.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - CC chemokines
AU - Mantovani, Alberto
AU - Locati, Massimo
AU - Sozzani, Silvano
PY - 2003/7/7
Y1 - 2003/7/7
N2 - This chapter focuses on CC chemokines, which are a complex system of molecules that affect a variety of hematopoietic and non-hematopoietic cell types. Validation as pharmacological targets includes gene targeting, usage of antibodies or antagonists, whose expression in human pathology is discussed in the chapter. CC chemokine receptor antagonists have been developed, and are at various stages of preclinical or clinical development. CC chemokines are the most numerous, and diversified family of the four subgroups defined, based on the Cys motif (CC, CXC, C, CX3C). In humans, it includes at least 25 members interacting with at least 11 signaling receptors. CC chemokines have been discovered following different pathways, ranging from biological, and biochemical identification to direct cDNA cloning to, more recently, in silico cloning by gene bank mining. The development of efficacious CC chemokine antagonists remains a "holy grail" for the general field of cytokine pharmacology. The chemokines role in the transition from innate to acquired immunity, and in amplification of polarized responses on selected molecules, and pathologies are used as a paradigm.
AB - This chapter focuses on CC chemokines, which are a complex system of molecules that affect a variety of hematopoietic and non-hematopoietic cell types. Validation as pharmacological targets includes gene targeting, usage of antibodies or antagonists, whose expression in human pathology is discussed in the chapter. CC chemokine receptor antagonists have been developed, and are at various stages of preclinical or clinical development. CC chemokines are the most numerous, and diversified family of the four subgroups defined, based on the Cys motif (CC, CXC, C, CX3C). In humans, it includes at least 25 members interacting with at least 11 signaling receptors. CC chemokines have been discovered following different pathways, ranging from biological, and biochemical identification to direct cDNA cloning to, more recently, in silico cloning by gene bank mining. The development of efficacious CC chemokine antagonists remains a "holy grail" for the general field of cytokine pharmacology. The chemokines role in the transition from innate to acquired immunity, and in amplification of polarized responses on selected molecules, and pathologies are used as a paradigm.
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U2 - 10.1016/B978-012689663-3/50051-X
DO - 10.1016/B978-012689663-3/50051-X
M3 - Chapter
AN - SCOPUS:84942863732
SN - 9780080518794
SN - 9780126896633
SP - 1083
EP - 1100
BT - The Cytokine Handbook
PB - Elsevier Inc.
ER -