CC chemokines

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)

Abstract

This chapter focuses on CC chemokines, which are a complex system of molecules that affect a variety of hematopoietic and non-hematopoietic cell types. Validation as pharmacological targets includes gene targeting, usage of antibodies or antagonists, whose expression in human pathology is discussed in the chapter. CC chemokine receptor antagonists have been developed, and are at various stages of preclinical or clinical development. CC chemokines are the most numerous, and diversified family of the four subgroups defined, based on the Cys motif (CC, CXC, C, CX3C). In humans, it includes at least 25 members interacting with at least 11 signaling receptors. CC chemokines have been discovered following different pathways, ranging from biological, and biochemical identification to direct cDNA cloning to, more recently, in silico cloning by gene bank mining. The development of efficacious CC chemokine antagonists remains a "holy grail" for the general field of cytokine pharmacology. The chemokines role in the transition from innate to acquired immunity, and in amplification of polarized responses on selected molecules, and pathologies are used as a paradigm.

Original languageEnglish
Title of host publicationThe Cytokine Handbook
PublisherElsevier Inc.
Pages1083-1100
Number of pages18
ISBN (Print)9780080518794, 9780126896633
DOIs
Publication statusPublished - Jul 7 2003

Fingerprint

CX3C Chemokines
C Chemokines
Organism Cloning
Pharmacology
Pathology
Gene Targeting
Chemokine Receptors
Adaptive Immunity
Chemokines
Computer Simulation
Complementary DNA
Cytokines
Antibodies
Genes

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Mantovani, A., Locati, M., & Sozzani, S. (2003). CC chemokines. In The Cytokine Handbook (pp. 1083-1100). Elsevier Inc.. https://doi.org/10.1016/B978-012689663-3/50051-X

CC chemokines. / Mantovani, Alberto; Locati, Massimo; Sozzani, Silvano.

The Cytokine Handbook. Elsevier Inc., 2003. p. 1083-1100.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mantovani, A, Locati, M & Sozzani, S 2003, CC chemokines. in The Cytokine Handbook. Elsevier Inc., pp. 1083-1100. https://doi.org/10.1016/B978-012689663-3/50051-X
Mantovani A, Locati M, Sozzani S. CC chemokines. In The Cytokine Handbook. Elsevier Inc. 2003. p. 1083-1100 https://doi.org/10.1016/B978-012689663-3/50051-X
Mantovani, Alberto ; Locati, Massimo ; Sozzani, Silvano. / CC chemokines. The Cytokine Handbook. Elsevier Inc., 2003. pp. 1083-1100
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