CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4+ T cells: Role of signal transduction

Audrey Kinter, Andrew Catanzaro, Joan Monaco, Margaret Ruiz, Jesse Justement, Susan Moir, James Arthos, Alessandra Oliva, Linda Ehler, Stephanie Mizell, Robert Jackson, Mario Ostrowski, James Hoxie, Robin Offord, Anthony S. Fauci

Research output: Contribution to journalArticlepeer-review

Abstract

This study demonstrates that several CC-chemokines, including those that inhibit entry and replication of macrophage-tropic strains of HIV, increase the replication of T cell (T)-tropic strains in CD4+ T cells. Enhancement of T-tropic HIV replication is observed at early stages of replication, requires signaling through inhibitory guanine nucleotide-binding regulatory (G(i)) proteins, and is associated with increased cell surface colocalization of CD4 and the T-tropic HIV coreceptor CXCR4. These findings may further our understanding of the factors that influence the replication and spread of T-tropic strains of HIV in vivo and suggest that the use of cell signaling CC-chemokines as therapeutic agents for the purpose of limiting HIV replication in vivo should be approached with caution.

Original languageEnglish
Pages (from-to)11880-11885
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number20
DOIs
Publication statusPublished - Sep 29 1998

ASJC Scopus subject areas

  • Genetics
  • General

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