CCL19 and CXCL12 Trigger in Vitro Chemotaxis of Human Mantle Cell Lymphoma B Cells

Anna Corcione, Nicoletta Arduino, Elisa Ferretti, Lizzia Raffaghello, Silvio Roncella, Davide Rossi, Franco Fedeli, Luciano Ottonello, Livio Trentin, Franco Dallegri, Gianpietro Semenzato, Vito Pistoia

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Few data are available in the literature on chemokine receptor expression and migratory capability of mantle cell lymphoma (MCL) B cells. Information on these issues may allow us to identify novel mechanisms of chemokine-driven tumor cell migration. Experimental Design: The research was designed to investigate: (a) expression of CCR1 to CCR7 and CXCR1 to CXCR5 chemokine receptors; and (b) chemotaxis to the respective ligands in MCL B cells and in their normal counterparts, i.e., CD5+ B cells. Results: Malignant B cells from MCL patients and normal counterparts displayed similar chemokine receptor profiles. MCL B cells were induced to migrate by CXCL12 and CCL19, whereas normal CD5+ B cells migrated to the former, but not the latter chemokine. Overnight culture of MCL B cells and their normal counterparts with CXCL12 cross-sensitized other chemokine receptors to their ligands in some tumor samples but not in CD5+ B cells. Conclusions: CCR7 and CXCR4 ligands may play a key role in tumor cell migration and spreading in vivo. CXCL12 may additionally contribute by sensitizing MCL B cells to respond to the ligands of other chemokine receptors.

Original languageEnglish
Pages (from-to)964-971
Number of pages8
JournalClinical Cancer Research
Volume10
Issue number3
DOIs
Publication statusPublished - Feb 1 2004

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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