CCL19 and CXCL12 Trigger in Vitro Chemotaxis of Human Mantle Cell Lymphoma B Cells

Anna Corcione, Nicoletta Arduino, Elisa Ferretti, Lizzia Raffaghello, Silvio Roncella, Davide Rossi, Franco Fedeli, Luciano Ottonello, Livio Trentin, Franco Dallegri, Gianpietro Semenzato, Vito Pistoia

Research output: Contribution to journalArticle

Abstract

Purpose: Few data are available in the literature on chemokine receptor expression and migratory capability of mantle cell lymphoma (MCL) B cells. Information on these issues may allow us to identify novel mechanisms of chemokine-driven tumor cell migration. Experimental Design: The research was designed to investigate: (a) expression of CCR1 to CCR7 and CXCR1 to CXCR5 chemokine receptors; and (b) chemotaxis to the respective ligands in MCL B cells and in their normal counterparts, i.e., CD5+ B cells. Results: Malignant B cells from MCL patients and normal counterparts displayed similar chemokine receptor profiles. MCL B cells were induced to migrate by CXCL12 and CCL19, whereas normal CD5+ B cells migrated to the former, but not the latter chemokine. Overnight culture of MCL B cells and their normal counterparts with CXCL12 cross-sensitized other chemokine receptors to their ligands in some tumor samples but not in CD5+ B cells. Conclusions: CCR7 and CXCR4 ligands may play a key role in tumor cell migration and spreading in vivo. CXCL12 may additionally contribute by sensitizing MCL B cells to respond to the ligands of other chemokine receptors.

Original languageEnglish
Pages (from-to)964-971
Number of pages8
JournalClinical Cancer Research
Volume10
Issue number3
DOIs
Publication statusPublished - Feb 1 2004

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Mantle-Cell Lymphoma
Chemotaxis
B-Lymphocytes
Chemokine Receptors
Ligands
Chemokines
CXCR5 Receptors
Cell Movement
In Vitro Techniques
Neoplasms
Research Design

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

CCL19 and CXCL12 Trigger in Vitro Chemotaxis of Human Mantle Cell Lymphoma B Cells. / Corcione, Anna; Arduino, Nicoletta; Ferretti, Elisa; Raffaghello, Lizzia; Roncella, Silvio; Rossi, Davide; Fedeli, Franco; Ottonello, Luciano; Trentin, Livio; Dallegri, Franco; Semenzato, Gianpietro; Pistoia, Vito.

In: Clinical Cancer Research, Vol. 10, No. 3, 01.02.2004, p. 964-971.

Research output: Contribution to journalArticle

Corcione, A, Arduino, N, Ferretti, E, Raffaghello, L, Roncella, S, Rossi, D, Fedeli, F, Ottonello, L, Trentin, L, Dallegri, F, Semenzato, G & Pistoia, V 2004, 'CCL19 and CXCL12 Trigger in Vitro Chemotaxis of Human Mantle Cell Lymphoma B Cells', Clinical Cancer Research, vol. 10, no. 3, pp. 964-971. https://doi.org/10.1158/1078-0432.CCR-1182-3
Corcione, Anna ; Arduino, Nicoletta ; Ferretti, Elisa ; Raffaghello, Lizzia ; Roncella, Silvio ; Rossi, Davide ; Fedeli, Franco ; Ottonello, Luciano ; Trentin, Livio ; Dallegri, Franco ; Semenzato, Gianpietro ; Pistoia, Vito. / CCL19 and CXCL12 Trigger in Vitro Chemotaxis of Human Mantle Cell Lymphoma B Cells. In: Clinical Cancer Research. 2004 ; Vol. 10, No. 3. pp. 964-971.
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