CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions

M. Krumbholz, D. Theil, F. Steinmeyer, S. Cepok, B. Hemmer, M. Hofbauer, C. Farina, T. Derfuss, A. Junker, T. Arzberger, I. Sinicina, C. Hartle, J. Newcombe, R. Hohlfeld, E. Meinl

Research output: Contribution to journalArticle

Abstract

CCL19 and CCL21 bind to CCR7, which is crucial for both inducing an immune response and establishing immunological tolerance. We report that in the normal human brain CCL19, but not CCL21, is transcribed, and detectable as a protein in tissue lysates and in cerebrospinal fluid. In both active and inactive multiple sclerosis (MS) lesions CCL19 transcripts were elevated. In cerebrospinal fluid from MS and OIND patients CCL19 protein was increased. In relapsing-remitting and secondary progressive MS patients CCL19 correlated with intrathecal IgG production. This study suggests that CCL19 plays a role in both the physiological immunosurveillance of the healthy CNS and the pathological maintenance of immune cells in the CNS of MS patients.

Original languageEnglish
Pages (from-to)72-79
Number of pages8
JournalJournal of Neuroimmunology
Volume190
Issue number1-2
DOIs
Publication statusPublished - Oct 2007

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Multiple Sclerosis
Cerebrospinal Fluid
Chronic Progressive Multiple Sclerosis
Immunologic Monitoring
Proteins
Immunoglobulin G
Maintenance
Brain

Keywords

  • Chemokines
  • CSF
  • ELISA
  • Immunosurveillance
  • Multiple sclerosis
  • Taqman

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions. / Krumbholz, M.; Theil, D.; Steinmeyer, F.; Cepok, S.; Hemmer, B.; Hofbauer, M.; Farina, C.; Derfuss, T.; Junker, A.; Arzberger, T.; Sinicina, I.; Hartle, C.; Newcombe, J.; Hohlfeld, R.; Meinl, E.

In: Journal of Neuroimmunology, Vol. 190, No. 1-2, 10.2007, p. 72-79.

Research output: Contribution to journalArticle

Krumbholz, M, Theil, D, Steinmeyer, F, Cepok, S, Hemmer, B, Hofbauer, M, Farina, C, Derfuss, T, Junker, A, Arzberger, T, Sinicina, I, Hartle, C, Newcombe, J, Hohlfeld, R & Meinl, E 2007, 'CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions', Journal of Neuroimmunology, vol. 190, no. 1-2, pp. 72-79. https://doi.org/10.1016/j.jneuroim.2007.07.024
Krumbholz, M. ; Theil, D. ; Steinmeyer, F. ; Cepok, S. ; Hemmer, B. ; Hofbauer, M. ; Farina, C. ; Derfuss, T. ; Junker, A. ; Arzberger, T. ; Sinicina, I. ; Hartle, C. ; Newcombe, J. ; Hohlfeld, R. ; Meinl, E. / CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions. In: Journal of Neuroimmunology. 2007 ; Vol. 190, No. 1-2. pp. 72-79.
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AU - Cepok, S.

AU - Hemmer, B.

AU - Hofbauer, M.

AU - Farina, C.

AU - Derfuss, T.

AU - Junker, A.

AU - Arzberger, T.

AU - Sinicina, I.

AU - Hartle, C.

AU - Newcombe, J.

AU - Hohlfeld, R.

AU - Meinl, E.

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AB - CCL19 and CCL21 bind to CCR7, which is crucial for both inducing an immune response and establishing immunological tolerance. We report that in the normal human brain CCL19, but not CCL21, is transcribed, and detectable as a protein in tissue lysates and in cerebrospinal fluid. In both active and inactive multiple sclerosis (MS) lesions CCL19 transcripts were elevated. In cerebrospinal fluid from MS and OIND patients CCL19 protein was increased. In relapsing-remitting and secondary progressive MS patients CCL19 correlated with intrathecal IgG production. This study suggests that CCL19 plays a role in both the physiological immunosurveillance of the healthy CNS and the pathological maintenance of immune cells in the CNS of MS patients.

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