CCL8/MCP-2 association analysis in patients with Alzheimer's disease and frontotemporal lobar degeneration

Chiara Villa, Eliana Venturelli, Chiara Fenoglio, Francesca Clerici, Alessandra Marcone, Luisa Benussi, Roberta Ghidoni, Salvatore Gallone, Francesca Cortini, Diego Scalabrini, Maria Serpente, Giuliano Binetti, Stefano Cappa, Claudio Mariani, Innocenzo Rainero, Nereo Bresolin, Elio Scarpini, Daniela Galimberti

Research output: Contribution to journalArticle

Abstract

CCL2/Monocyte Chemoattractant Protein (MCP)-1 and other chemokines sharing a similar sequence, including CCL8/MCP-2, are involved in neurodegeneration. A few Single Nucleotide Polymorphisms (SNPs) have been reported in CCL8/MCP-2, all of which are located in the same linkage block. One of them (rs1163763) leads to an aminoacidic substitution, implying a potential impact on the function of the protein. rs1133763 was tested for association in 219 patients with Alzheimer's disease (AD) and 209 with Frontotemporal Lobar Degeneration (FTLD) as compared with 231 age-matched controls. The distribution of CCL8/MCP-2 rs1133763 was not significantly different among patients with AD or FTLD and controls, even stratifying according to gender. CCL8/MCP rs1133763 SNP, or other variants in linkage disequilibrium with this variant, likely do not influence the susceptibility to AD or FTLD in Caucasians.

Original languageEnglish
Pages (from-to)1379-1381
Number of pages3
JournalJournal of Neurology
Volume256
Issue number8
DOIs
Publication statusPublished - Aug 2009

Keywords

  • Alzheimer's disease
  • CCL8/MCP-2
  • Frontotemporal lobar degeneration
  • Risk factor

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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