CCR2-64I polymorphism and CCR5Δ32 deletion in patients with Alzheimer's disease

Daniela Galimberti, Chiara Fenoglio, Carlo Lovati, Alberto Gatti, Ilaria Guidi, Eliana Venturelli, Gary R. Cutter, Claudio Mariani, Gianluigi Forloni, Carla Pettenati, Pierluigi Baron, Giancarlo Conti, Nereo Bresolin, Elio Scarpini

Research output: Contribution to journalArticlepeer-review

Abstract

Monocyte chemoattractant protein-1 (MCP-1) and RANTES, as well as their related receptors, have been shown to be involved in Alzheimer's disease (AD) pathogenesis. Genes for their related receptors, CCR2 and CCR5, respectively, are characterized by the presence of two polymorphisms: a conservative change of a valine with an isoleucine at codon 64 of CCR2 (CCR2-64I) and a 32-bp deletion in the coding region of CCR5 (CCR5Δ32), which leads to the expression of a nonfunctional receptor. The distribution of the CCR2-64I and CCR5Δ32 polymorphisms was determined in 290 AD patients and in 222 controls. A decreased frequency and an absence of homozygous for the polymorphism CCR2-64I were found, thus suggesting a protective effect of the mutated allele on the occurrence of AD. However, these findings must be cautiously interpreted as the overall significance was found without adjustment for multiple comparisons and is coming from the complete absence of the genotype 64I/64I in AD patients. Conversely, no different distribution of the CCR5Δ32 deletion in the two populations was shown. Stratifying by the presence of ApoE ε4 allele, gender or age at onset, no differences in either allele frequencies were observed.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalJournal of the Neurological Sciences
Volume225
Issue number1-2
DOIs
Publication statusPublished - Oct 15 2004

Keywords

  • Alzheimer's disease
  • Chemokines
  • Genetics
  • MCP-1
  • RANTES
  • Receptors

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

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