CCR3 gene overexpression in patients with Down syndrome

Michele Salemi, Rossella Cannarella, Giovanna Marchese, Maria Grazia Salluzzo, Maria Ravo, Concetta Barone, Angela Cordella, Salvatore Caniglia, Roberto Castiglione, Alda Ragalmuto, Aldo E. Calogero, Corrado Romano

Research output: Contribution to journalArticlepeer-review


Chromosome 21 trisomy or Down syndrome (DS) is the most common genetic cause of intellectual disability (ID). DS is also associated with hypotonia, muscle weakness, autoimmune diseases, and congenital heart disease. C–C chemokine receptor type 3 (CCR3) plays a role in inflammatory, autoimmune, and neuronal migration mechanisms. The present study aimed to evaluate the expression of the CCR3 gene by NGS and qRT-PCR in patients with DS and normal controls (NC). The CCR3 gene was over-expressed in DS patients compared to NC. These data suggest that an over-expression of the CCR3 gene is associated with the phenotype of patients with DS.

Original languageEnglish
Pages (from-to)5335-5338
Number of pages4
JournalMolecular Biology Reports
Issue number6
Publication statusPublished - Jun 2021


  • CCR3
  • Down syndrome
  • Intellectual disability
  • NGS
  • qRT-PCR

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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