TY - JOUR
T1 - CD nomenclature 2015
T2 - Human leukocyte differentiation antigen workshops as a driving force in immunology
AU - Engel, Pablo
AU - Boumsell, Laurence
AU - Balderas, Robert
AU - Bensussan, Armand
AU - Gattei, Valter
AU - Horejsi, Vaclav
AU - Jin, Bo Quan
AU - Malavasi, Fabio
AU - Mortari, Frank
AU - Schwartz-Albiez, Reinhard
AU - Stockinger, Hannes
AU - Van Zelm, Menno C.
AU - Zola, Heddy
AU - Clark, Georgina
PY - 2015/11/15
Y1 - 2015/11/15
N2 - CD(cluster of differentiation) Ags are cell surfacemolecules expressed on leukocytes and other cells relevant for the immune system. CDnomenclature has been universally adopted by the scientific community and is officially approved by the International Union of Immunological Societies and sanctioned by the World Health Organization. It provides a unified designation system for mAbs, as well as for the cell surface molecules that they recognize. This nomenclature was established by the Human Leukocyte Differentiation Antigens Workshops. In addition to defining the CDnomenclature, these workshops have been instrumental in identifying and determining the expression and function of cell surface molecules. Over the past 30 y, the data generated by the 10 Human Leukocyte Differentiation Antigens Workshops have led to the characterization and formal designation of more than 400 molecules. CD molecules are commonly used as cell markers, allowing the identification and isolation of leukocyte populations, subsets, and differentiation stages. mAbs against these molecules have proven to be essential for biomedical research and diagnosis, as well as in biotechnology. More recently, they have been recognized as invaluable tools for the treatment of several malignancies and autoimmune diseases. In this article, we describe how the CD nomenclature was established, present the official updated list of CD molecules, and provide a rationale for their usefulness in the 21st century.
AB - CD(cluster of differentiation) Ags are cell surfacemolecules expressed on leukocytes and other cells relevant for the immune system. CDnomenclature has been universally adopted by the scientific community and is officially approved by the International Union of Immunological Societies and sanctioned by the World Health Organization. It provides a unified designation system for mAbs, as well as for the cell surface molecules that they recognize. This nomenclature was established by the Human Leukocyte Differentiation Antigens Workshops. In addition to defining the CDnomenclature, these workshops have been instrumental in identifying and determining the expression and function of cell surface molecules. Over the past 30 y, the data generated by the 10 Human Leukocyte Differentiation Antigens Workshops have led to the characterization and formal designation of more than 400 molecules. CD molecules are commonly used as cell markers, allowing the identification and isolation of leukocyte populations, subsets, and differentiation stages. mAbs against these molecules have proven to be essential for biomedical research and diagnosis, as well as in biotechnology. More recently, they have been recognized as invaluable tools for the treatment of several malignancies and autoimmune diseases. In this article, we describe how the CD nomenclature was established, present the official updated list of CD molecules, and provide a rationale for their usefulness in the 21st century.
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U2 - 10.4049/jimmunol.1502033
DO - 10.4049/jimmunol.1502033
M3 - Article
C2 - 26546687
AN - SCOPUS:84958649164
VL - 195
SP - 4555
EP - 4563
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 10
ER -