CD117 immunoreactivity in high-grade neuroendocrine tumors of the lung: A comparative study of 39 large-cell neuroendocrine carcinomas and 27 surgically resected small-cell carcinomas

Giuseppe Pelosi, Michele Masullo, Maria Elena Leon, Giulia Veronesi, Lorenzo Spaggiari, Felice Pasini, Angelica Sonzogni, Antonio Iannucci, Enrica Bresaola, Giuseppe Viale

Research output: Contribution to journalArticlepeer-review

Abstract

Little is known about CD117 prevalence and clinicopathological implications in pulmonary large-cell neuroendocrine carcinoma. We studied CD117 immunoreactivity in surgical specimens from 39 large-cell neuroendocrine carcinomas of stages I-III and 27 limited-disease small-cell carcinomas, 56 typical and atypical carcinoids of the lung, and 10 neuroendocrine tumorlets, including the membrane and cytoplasmic immunostaining patterns. Membrane CD117 immunoreactivity in 5% or more tumor cells was documented in 30 (77%) large-cell neuroendocrine carcinomas and 18 (67%) small-cell carcinomas and 4 (7%) carcinoids, whereas cytoplasmic labeling was seen in 17 (44%) large-cell neuroendocrine carcinomas, 19 (70%) small-cell carcinomas, and 3 (5%) carcinoids. None of the neuroendocrine cells of the normal bronchial epithelium and of 10 tumorlets showed any CD117 immunoreactivity. Cytoplasmic immunostaining was more prevalent in small-cell carcinomas, whereas membrane labeling did not differ between the two types of high-grade carcinomas. Downregulation of CD117 by neoadjuvant chemotherapy was seen in large-cell neuroendocrine carcinomas but not small-cell carcinomas. Multiple linear regression analysis demonstrated a marginal association between cytoplasmic CD117 immunoreactivity and regional lymph node metastasis in small-cell carcinomas but not large-cell neuroendocrine carcinomas. There was no association between CD117 immunoreactivity and survival in either small-cell carcinoma or large-cell neuroendocrine carcinoma patients.

Original languageEnglish
Pages (from-to)449-455
Number of pages7
JournalVirchows Archiv
Volume445
Issue number5
DOIs
Publication statusPublished - Nov 2004

Keywords

  • Carcinoma
  • CD117
  • Large-cell
  • Neuroendocrine
  • Small-cell

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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